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Revealing the immune perturbation of black phosphorus nanomaterials to macrophages by understanding the protein corona

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  • Jianbin Mo

    (Nanjing University
    Nanjing University)

  • Qingyun Xie

    (Chengdu Military General Hospital)

  • Wei Wei

    (Nanjing University
    Nanjing University)

  • Jing Zhao

    (Nanjing University)

Abstract

The increasing number of biological applications for black phosphorus (BP) nanomaterials has precipitated considerable concern about their interactions with physiological systems. Here we demonstrate the adsorption of plasma protein onto BP nanomaterials and the subsequent immune perturbation effect on macrophages. Using liquid chromatography tandem mass spectrometry, 75.8% of the proteins bound to BP quantum dots were immune relevant proteins, while that percentage for BP nanosheet–corona complexes is 69.9%. In particular, the protein corona dramatically reshapes BP nanomaterial–corona complexes, influenced cellular uptake, activated the NF-κB pathway and even increased cytokine secretion by 2–4-fold. BP nanomaterials induce immunotoxicity and immune perturbation in macrophages in the presence of a plasma corona. These findings offer important insights into the development of safe and effective BP nanomaterial-based therapies.

Suggested Citation

  • Jianbin Mo & Qingyun Xie & Wei Wei & Jing Zhao, 2018. "Revealing the immune perturbation of black phosphorus nanomaterials to macrophages by understanding the protein corona," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04873-7
    DOI: 10.1038/s41467-018-04873-7
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    Cited by:

    1. Du, Xiaosheng & Qiu, Jinghong & Deng, Sha & Du, Zongliang & Cheng, Xu & Wang, Haibo, 2021. "Flame-retardant and solid-solid phase change composites based on dopamine-decorated BP nanosheets/Polyurethane for efficient solar-to-thermal energy storage," Renewable Energy, Elsevier, vol. 164(C), pages 1-10.

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