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Sensory overamplification in layer 5 auditory corticofugal projection neurons following cochlear nerve synaptic damage

Author

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  • Meenakshi M. Asokan

    (Massachusetts Eye and Ear Infirmary
    Harvard University)

  • Ross S. Williamson

    (Massachusetts Eye and Ear Infirmary
    Harvard Medical School)

  • Kenneth E. Hancock

    (Massachusetts Eye and Ear Infirmary
    Harvard Medical School)

  • Daniel B. Polley

    (Massachusetts Eye and Ear Infirmary
    Harvard University
    Harvard Medical School)

Abstract

Layer 5 (L5) cortical projection neurons innervate far-ranging brain areas to coordinate integrative sensory processing and adaptive behaviors. Here, we characterize a plasticity in L5 auditory cortex (ACtx) neurons that innervate the inferior colliculus (IC), thalamus, lateral amygdala and striatum. We track daily changes in sound processing using chronic widefield calcium imaging of L5 axon terminals on the dorsal cap of the IC in awake, adult mice. Sound level growth functions at the level of the auditory nerve and corticocollicular axon terminals are both strongly depressed hours after noise-induced damage of cochlear afferent synapses. Corticocollicular response gain rebounded above baseline levels by the following day and remained elevated for several weeks despite a persistent reduction in auditory nerve input. Sustained potentiation of excitatory ACtx projection neurons that innervate multiple limbic and subcortical auditory centers may underlie hyperexcitability and aberrant functional coupling of distributed brain networks in tinnitus and hyperacusis.

Suggested Citation

  • Meenakshi M. Asokan & Ross S. Williamson & Kenneth E. Hancock & Daniel B. Polley, 2018. "Sensory overamplification in layer 5 auditory corticofugal projection neurons following cochlear nerve synaptic damage," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04852-y
    DOI: 10.1038/s41467-018-04852-y
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    Cited by:

    1. Koun Onodera & Hiroyuki K. Kato, 2022. "Translaminar recurrence from layer 5 suppresses superficial cortical layers," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Manoj Kumar & Gregory Handy & Stylianos Kouvaros & Yanjun Zhao & Lovisa Ljungqvist Brinson & Eric Wei & Brandon Bizup & Brent Doiron & Thanos Tzounopoulos, 2023. "Cell-type-specific plasticity of inhibitory interneurons in the rehabilitation of auditory cortex after peripheral damage," Nature Communications, Nature, vol. 14(1), pages 1-23, December.

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