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Uterine glands coordinate on-time embryo implantation and impact endometrial decidualization for pregnancy success

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  • Andrew M. Kelleher

    (University of Missouri)

  • Jessica Milano-Foster

    (University of Missouri)

  • Susanta K. Behura

    (University of Missouri)

  • Thomas E. Spencer

    (University of Missouri
    University of Missouri)

Abstract

Uterine glands are essential for pregnancy establishment. By employing forkhead box A2 (FOXA2)-deficient mouse models coupled with leukemia inhibitory factor (LIF) repletion, we reveal definitive roles of uterine glands in embryo implantation and stromal cell decidualization. Here we report that LIF from the uterine glands initiates embryo-uterine communication, leading to embryo attachment and stromal cell decidualization. Detailed histological and molecular analyses discovered that implantation crypt formation does not involve uterine glands, but removal of the luminal epithelium is delayed and subsequent decidualization fails in LIF-replaced glandless but not gland-containing FOXA2-deficient mice. Adverse ripple effects of those dysregulated events in the glandless uterus result in embryo resorption and pregnancy failure. These studies provide evidence that uterine glands synchronize embryo-endometrial interactions, coordinate on-time embryo implantation, and impact stromal cell decidualization, thereby ensuring embryo viability, placental growth, and pregnancy success.

Suggested Citation

  • Andrew M. Kelleher & Jessica Milano-Foster & Susanta K. Behura & Thomas E. Spencer, 2018. "Uterine glands coordinate on-time embryo implantation and impact endometrial decidualization for pregnancy success," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04848-8
    DOI: 10.1038/s41467-018-04848-8
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    Cited by:

    1. Sangappa B. Chadchan & Pooja Popli & Zian Liao & Eryk Andreas & Michelle Dias & Tianyuan Wang & Stephanie J. Gunderson & Patricia T. Jimenez & Denise G. Lanza & Rainer B. Lanz & Charles E. Foulds & Di, 2024. "A GREB1-steroid receptor feedforward mechanism governs differential GREB1 action in endometrial function and endometriosis," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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