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The REN4 rheostat dynamically coordinates the apical and lateral domains of Arabidopsis pollen tubes

Author

Listed:
  • Hui Li

    (Shanghai Institutes for Biological Sciences Chinese Academy of Sciences
    University of California
    East China Normal University)

  • Nan Luo

    (University of California
    Fujian Agriculture and Forestry University)

  • Weidong Wang

    (University of California)

  • Zengyu Liu

    (Fujian Agriculture and Forestry University)

  • Jisheng Chen

    (University of California
    Fujian Agriculture and Forestry University)

  • Liangtao Zhao

    (Shanghai Institutes for Biological Sciences Chinese Academy of Sciences)

  • Li Tan

    (Shanghai Institutes for Biological Sciences Chinese Academy of Sciences)

  • Chunyan Wang

    (Shanghai Institutes for Biological Sciences Chinese Academy of Sciences)

  • Yuan Qin

    (Fujian Agriculture and Forestry University)

  • Chao Li

    (East China Normal University)

  • Tongda Xu

    (Shanghai Institutes for Biological Sciences Chinese Academy of Sciences
    Fujian Agriculture and Forestry University)

  • Zhenbiao Yang

    (University of California
    Fujian Agriculture and Forestry University)

Abstract

The dynamic maintenance of polar domains in the plasma membrane (PM) is critical for many fundamental processes, e.g., polar cell growth and growth guidance but remains poorly characterized. Rapid tip growth of Arabidopsis pollen tubes requires dynamic distribution of active ROP1 GTPase to the apical domain. Here, we show that clathrin-mediated endocytosis (CME) coordinates lateral REN4 with apical ROP1 signaling. REN4 interacted with but antagonized active ROP1. REN4 also interacts and co-localizes with CME components, but exhibits an opposite role to CME, which removes both REN4 and active ROP1 from the PM. Mathematical modeling shows that REN4 restrains the spatial distribution of active ROP1 and is important for the robustness of polarity control. Hence our results indicate that REN4 acts as a spatiotemporal rheostat by interacting with ROP1 to initiate their removal from the PM by CME, thereby coordinating a dynamic demarcation between apical and lateral domains during rapid tip growth.

Suggested Citation

  • Hui Li & Nan Luo & Weidong Wang & Zengyu Liu & Jisheng Chen & Liangtao Zhao & Li Tan & Chunyan Wang & Yuan Qin & Chao Li & Tongda Xu & Zhenbiao Yang, 2018. "The REN4 rheostat dynamically coordinates the apical and lateral domains of Arabidopsis pollen tubes," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04838-w
    DOI: 10.1038/s41467-018-04838-w
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    Cited by:

    1. David M. Rutkowski & Vincent Vincenzetti & Dimitrios Vavylonis & Sophie G. Martin, 2024. "Cdc42 mobility and membrane flows regulate fission yeast cell shape and survival," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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