IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-04802-8.html
   My bibliography  Save this article

Continuous biomarker monitoring by particle mobility sensing with single molecule resolution

Author

Listed:
  • Emiel W. A. Visser

    (Eindhoven University of Technology
    Eindhoven University of Technology)

  • Junhong Yan

    (Eindhoven University of Technology
    Eindhoven University of Technology)

  • Leo J. IJzendoorn

    (Eindhoven University of Technology
    Eindhoven University of Technology)

  • Menno W. J. Prins

    (Eindhoven University of Technology
    Eindhoven University of Technology
    Eindhoven University of Technology)

Abstract

Healthcare is in demand of technologies for real-time sensing in order to continuously guard the state of patients. Here we present biomarker-monitoring based on the sensing of particle mobility, a concept wherein particles are coupled to a substrate via a flexible molecular tether, with both the particles and substrate provided with affinity molecules for effectuating specific and reversible interactions. Single-molecular binding and unbinding events modulate the Brownian particle motion and the state changes are recorded using optical scattering microscopy. The technology is demonstrated with DNA and protein as model biomarkers, in buffer and in blood plasma, showing sensitivity to picomolar and nanomolar concentrations. The sensing principle is direct and self-contained, without consuming or producing any reactants. With its basis in reversible interactions and single-molecule resolution, we envisage that the presented technology will enable biosensors for continuous biomarker monitoring with high sensitivity, specificity, and accuracy.

Suggested Citation

  • Emiel W. A. Visser & Junhong Yan & Leo J. IJzendoorn & Menno W. J. Prins, 2018. "Continuous biomarker monitoring by particle mobility sensing with single molecule resolution," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04802-8
    DOI: 10.1038/s41467-018-04802-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-04802-8
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-04802-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yaning Liu & Haihang Ye & HoangDinh Huynh & Chen Xie & Peiyuan Kang & Jeffrey S. Kahn & Zhenpeng Qin, 2022. "Digital plasmonic nanobubble detection for rapid and ultrasensitive virus diagnostics," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Alissa D. Buskermolen & Yu-Ting Lin & Laura Smeden & Rik B. Haaften & Junhong Yan & Khulan Sergelen & Arthur M. Jong & Menno W. J. Prins, 2022. "Continuous biomarker monitoring with single molecule resolution by measuring free particle motion," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04802-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.