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Soft transparent graphene contact lens electrodes for conformal full-cornea recording of electroretinogram

Author

Listed:
  • Rongkang Yin

    (Peking University
    Peking University
    Peking University
    Peking University)

  • Zheng Xu

    (Peking University
    Peking University)

  • Ming Mei

    (WuXi App Tec (Suzhou) Co., Ltd)

  • Zhaolong Chen

    (Peking University
    Peking University)

  • Kai Wang

    (Peking University People’s Hospital
    Peking University Health Science Center)

  • Yanlin Liu

    (Peking University People’s Hospital
    Peking University Health Science Center)

  • Tao Tang

    (Peking University People’s Hospital
    Peking University Health Science Center)

  • Manish Kr. Priydarshi

    (Peking University
    Peking University)

  • Xuejuan Meng

    (Peking University
    Peking University)

  • Siyuan Zhao

    (Peking University
    Peking University
    Peking University)

  • Bing Deng

    (Peking University
    Peking University)

  • Hailin Peng

    (Peking University
    Peking University
    Peking University)

  • Zhongfan Liu

    (Peking University
    Peking University
    Peking University)

  • Xiaojie Duan

    (Peking University
    Peking University
    Peking University)

Abstract

Visual electrophysiology measurements are important for ophthalmic diagnostic testing. Electrodes with combined optical transparency and softness are highly desirable, and sometimes indispensable for many ocular electrophysiology measurements. Here we report the fabrication of soft graphene contact lens electrodes (GRACEs) with broad-spectrum optical transparency, and their application in conformal, full-cornea recording of electroretinography (ERG) from cynomolgus monkeys. The GRACEs give higher signal amplitude than conventional ERG electrodes in recordings of various full-field ERG responses. High-quality topographic mapping of multifocal ERG under simultaneous fundus monitoring is realized. A conformal and tight interface between the GRACEs and cornea is revealed. Neither corneal irritation nor abnormal behavior of the animals is observed after ERG measurements with GRACEs. Furthermore, spatially resolved ERG recordings on rabbits with graphene multi-electrode array reveal a stronger signal at the central cornea than the periphery. These results demonstrate the unique capabilities of the graphene-based electrodes for in vivo visual electrophysiology studies.

Suggested Citation

  • Rongkang Yin & Zheng Xu & Ming Mei & Zhaolong Chen & Kai Wang & Yanlin Liu & Tao Tang & Manish Kr. Priydarshi & Xuejuan Meng & Siyuan Zhao & Bing Deng & Hailin Peng & Zhongfan Liu & Xiaojie Duan, 2018. "Soft transparent graphene contact lens electrodes for conformal full-cornea recording of electroretinogram," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04781-w
    DOI: 10.1038/s41467-018-04781-w
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    Cited by:

    1. Jinyuan Zhang & Kyunghun Kim & Ho Joong Kim & Dawn Meyer & Woohyun Park & Seul Ah Lee & Yumin Dai & Bongjoong Kim & Haesoo Moon & Jay V. Shah & Keely E. Harris & Brett Collar & Kangying Liu & Pedro Ir, 2022. "Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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