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Near infrared fluorescent peptide nanoparticles for enhancing esophageal cancer therapeutic efficacy

Author

Listed:
  • Zhen Fan

    (Tongji University
    Tongji University
    The Ohio State University
    The Ohio State University Wexner Medical Center)

  • Yan Chang

    (The University of Texas at Arlington)

  • Chaochu Cui

    (The University of Texas at Arlington
    Sun Yat-sen University Cancer Center
    Xinxiang Medical University)

  • Leming Sun

    (Northwestern Polytechnical University)

  • David H. Wang

    (University of Texas Southwestern Medical Center
    VA North Texas Health Care System)

  • Zui Pan

    (The University of Texas at Arlington)

  • Mingjun Zhang

    (The Ohio State University
    The Ohio State University Wexner Medical Center
    The Ohio State University)

Abstract

Various types of nanoparticles have been proposed for targeted drug delivering, imaging, and tracking of therapeutic agents. However, highly biocompatible nanoparticles with structure-induced fluorescence and capability to conjugate with biomarkers and drugs remain lacking. This research proposes and synthesizes fluorescent nanoparticles (f-PNPs) assembled by cyclic peptides to combine imaging and drug delivering for esophageal cancer (EC). To achieve tumor targeting, f-PNPs are first conjugated with RGD moieties to selectively target EC cells via αvβ3 integrin; the nanoparticles are then embedded with epirubicin (EPI). Cell viability assays and analysis of tissue histology reveal that EPI-loaded RGD-f-PNPs (RGD-f-PNPs/EPI) led to significantly reduced cardiotoxicity and improved anti-tumor activity compared to EPI alone. Moreover, the drug delivery to tumor sites and therapeutic responses could be monitored with near-infrared fluorescence using RGD-f-PNPs/EPI. This unique nanoparticle system may lead to potential approaches for bioorganic fluorescence-based delivering, imaging, and drug release tracking.

Suggested Citation

  • Zhen Fan & Yan Chang & Chaochu Cui & Leming Sun & David H. Wang & Zui Pan & Mingjun Zhang, 2018. "Near infrared fluorescent peptide nanoparticles for enhancing esophageal cancer therapeutic efficacy," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04763-y
    DOI: 10.1038/s41467-018-04763-y
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