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Spatially confined lignin nanospheres for biocatalytic ester synthesis in aqueous media

Author

Listed:
  • Mika Henrikki Sipponen

    (Aalto University)

  • Muhammad Farooq

    (Aalto University)

  • Jari Koivisto

    (Aalto University)

  • Alessandro Pellis

    (University of York, Heslington)

  • Jani Seitsonen

    (Aalto University)

  • Monika Österberg

    (Aalto University)

Abstract

Dehydration reactions proceed readily in water-filled biological cells. Development of biocatalysts that mimic such compartmentalized reactions has been cumbersome due to the lack of low-cost nanomaterials and associated technologies. Here we show that cationic lignin nanospheres function as activating anchors for hydrolases, and enable aqueous ester synthesis by forming spatially confined biocatalysts upon self-assembly and drying-driven aggregation in calcium alginate hydrogel. Spatially confined microbial cutinase and lipase retain 97% and 70% of their respective synthetic activities when the volume ratio of water to hexane increases from 1:1 to 9:1 in the reaction medium. The activity retention of industrially most frequently used acrylic resin-immobilized Candida antarctica lipase B is only 51% under similar test conditions. Overall, our findings enable fabrication of robust renewable biocatalysts for aqueous ester synthesis, and provide insight into the compartmentalization of diverse heterogeneous catalysts.

Suggested Citation

  • Mika Henrikki Sipponen & Muhammad Farooq & Jari Koivisto & Alessandro Pellis & Jani Seitsonen & Monika Österberg, 2018. "Spatially confined lignin nanospheres for biocatalytic ester synthesis in aqueous media," Nature Communications, Nature, vol. 9(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04715-6
    DOI: 10.1038/s41467-018-04715-6
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