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Interplay of the two ancient metabolites auxin and MEcPP regulates adaptive growth

Author

Listed:
  • Jishan Jiang

    (University of California)

  • Cecilia Rodriguez-Furlan

    (University of California)

  • Jin-Zheng Wang

    (University of California)

  • Amancio de Souza

    (University of California)

  • Haiyan Ke

    (University of California)

  • Taras Pasternak

    (University of Freiburg, Faculty of Biology; BIOSS Centre for Biological Signaling Studies and ZBSA Centre for Biosystems Studies)

  • Hanna Lasok

    (University of Freiburg, Faculty of Biology; BIOSS Centre for Biological Signaling Studies and ZBSA Centre for Biosystems Studies)

  • Franck A. Ditengou

    (University of Freiburg, Faculty of Biology; BIOSS Centre for Biological Signaling Studies and ZBSA Centre for Biosystems Studies)

  • Klaus Palme

    (University of Freiburg, Faculty of Biology; BIOSS Centre for Biological Signaling Studies and ZBSA Centre for Biosystems Studies)

  • Katayoon Dehesh

    (University of California)

Abstract

The ancient morphoregulatory hormone auxin dynamically realigns dedicated cellular processes that shape plant growth under prevailing environmental conditions. However, the nature of the stress-responsive signal altering auxin homeostasis remains elusive. Here we establish that the evolutionarily conserved plastidial retrograde signaling metabolite methylerythritol cyclodiphosphate (MEcPP) controls adaptive growth by dual transcriptional and post-translational regulatory inputs that modulate auxin levels and distribution patterns in response to stress. We demonstrate that in vivo accumulation or exogenous application of MEcPP alters the expression of two auxin reporters, DR5:GFP and DII-VENUS, and reduces the abundance of the auxin-efflux carrier PIN-FORMED1 (PIN1) at the plasma membrane. However, pharmacological intervention with clathrin-mediated endocytosis blocks the PIN1 reduction. This study provides insight into the interplay between these two indispensable signaling metabolites by establishing the mode of MEcPP action in altering auxin homeostasis, and as such, positioning plastidial function as the primary driver of adaptive growth.

Suggested Citation

  • Jishan Jiang & Cecilia Rodriguez-Furlan & Jin-Zheng Wang & Amancio de Souza & Haiyan Ke & Taras Pasternak & Hanna Lasok & Franck A. Ditengou & Klaus Palme & Katayoon Dehesh, 2018. "Interplay of the two ancient metabolites auxin and MEcPP regulates adaptive growth," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04708-5
    DOI: 10.1038/s41467-018-04708-5
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    Cited by:

    1. Jordi Perez-Gil & James Behrendorff & Andrew Douw & Claudia E. Vickers, 2024. "The methylerythritol phosphate pathway as an oxidative stress sense and response system," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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