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Diversity and evolution of the emerging Pandoraviridae family

Author

Listed:
  • Matthieu Legendre

    (UMR 7256 (IMM FR 3479))

  • Elisabeth Fabre

    (UMR 7256 (IMM FR 3479))

  • Olivier Poirot

    (UMR 7256 (IMM FR 3479))

  • Sandra Jeudy

    (UMR 7256 (IMM FR 3479))

  • Audrey Lartigue

    (UMR 7256 (IMM FR 3479))

  • Jean-Marie Alempic

    (UMR 7256 (IMM FR 3479))

  • Laure Beucher

    (BIG-BGE)

  • Nadège Philippe

    (UMR 7256 (IMM FR 3479))

  • Lionel Bertaux

    (UMR 7256 (IMM FR 3479))

  • Eugène Christo-Foroux

    (UMR 7256 (IMM FR 3479))

  • Karine Labadie

    (Centre National de Séquençage)

  • Yohann Couté

    (BIG-BGE)

  • Chantal Abergel

    (UMR 7256 (IMM FR 3479))

  • Jean-Michel Claverie

    (UMR 7256 (IMM FR 3479))

Abstract

With DNA genomes reaching 2.5 Mb packed in particles of bacterium-like shape and dimension, the first two Acanthamoeba-infecting pandoraviruses remained up to now the most complex viruses since their discovery in 2013. Our isolation of three new strains from distant locations and environments is now used to perform the first comparative genomics analysis of the emerging worldwide-distributed Pandoraviridae family. Thorough annotation of the genomes combining transcriptomic, proteomic, and bioinformatic analyses reveals many non-coding transcripts and significantly reduces the former set of predicted protein-coding genes. Here we show that the pandoraviruses exhibit an open pan-genome, the enormous size of which is not adequately explained by gene duplications or horizontal transfers. As most of the strain-specific genes have no extant homolog and exhibit statistical features comparable to intergenic regions, we suggest that de novo gene creation could contribute to the evolution of the giant pandoravirus genomes.

Suggested Citation

  • Matthieu Legendre & Elisabeth Fabre & Olivier Poirot & Sandra Jeudy & Audrey Lartigue & Jean-Marie Alempic & Laure Beucher & Nadège Philippe & Lionel Bertaux & Eugène Christo-Foroux & Karine Labadie &, 2018. "Diversity and evolution of the emerging Pandoraviridae family," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04698-4
    DOI: 10.1038/s41467-018-04698-4
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    Cited by:

    1. Hugo Bisio & Matthieu Legendre & Claire Giry & Nadege Philippe & Jean-Marie Alempic & Sandra Jeudy & Chantal Abergel, 2023. "Evolution of giant pandoravirus revealed by CRISPR/Cas9," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Sofia Rigou & Sébastien Santini & Chantal Abergel & Jean-Michel Claverie & Matthieu Legendre, 2022. "Past and present giant viruses diversity explored through permafrost metagenomics," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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