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Diverse populations of local interneurons integrate into the Drosophila adult olfactory circuit

Author

Listed:
  • Nan-Fu Liou

    (Academia Sinica)

  • Shih-Han Lin

    (Academia Sinica)

  • Ying-Jun Chen

    (Academia Sinica)

  • Kuo-Ting Tsai

    (Academia Sinica)

  • Chi-Jen Yang

    (Academia Sinica)

  • Tzi-Yang Lin

    (Academia Sinica
    Research Institute of Molecular Pathology (IMP), Vienna Biocenter)

  • Ting-Han Wu

    (Academia Sinica)

  • Hsin-Ju Lin

    (Academia Sinica)

  • Yuh-Tarng Chen

    (Academia Sinica)

  • Daryl M. Gohl

    (Stanford University
    University of Minnesota Genomics Center)

  • Marion Silies

    (Stanford University
    University Medical Center Göttingen)

  • Ya-Hui Chou

    (Academia Sinica
    Academia Sinica)

Abstract

Drosophila olfactory local interneurons (LNs) in the antennal lobe are highly diverse and variable. How and when distinct types of LNs emerge, differentiate, and integrate into the olfactory circuit is unknown. Through systematic developmental analyses, we found that LNs are recruited to the adult olfactory circuit in three groups. Group 1 LNs are residual larval LNs. Group 2 are adult-specific LNs that emerge before cognate sensory and projection neurons establish synaptic specificity, and Group 3 LNs emerge after synaptic specificity is established. Group 1 larval LNs are selectively reintegrated into the adult circuit through pruning and re-extension of processes to distinct regions of the antennal lobe, while others die during metamorphosis. Precise temporal control of this pruning and cell death shapes the global organization of the adult antennal lobe. Our findings provide a road map to understand how LNs develop and contribute to constructing the olfactory circuit.

Suggested Citation

  • Nan-Fu Liou & Shih-Han Lin & Ying-Jun Chen & Kuo-Ting Tsai & Chi-Jen Yang & Tzi-Yang Lin & Ting-Han Wu & Hsin-Ju Lin & Yuh-Tarng Chen & Daryl M. Gohl & Marion Silies & Ya-Hui Chou, 2018. "Diverse populations of local interneurons integrate into the Drosophila adult olfactory circuit," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04675-x
    DOI: 10.1038/s41467-018-04675-x
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