IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-04673-z.html
   My bibliography  Save this article

Brain-actuated functional electrical stimulation elicits lasting arm motor recovery after stroke

Author

Listed:
  • A. Biasiucci

    (École Polytechnique Fédérale de Lausanne)

  • R. Leeb

    (École Polytechnique Fédérale de Lausanne
    École Polytechnique Fédérale de Lausanne)

  • I. Iturrate

    (École Polytechnique Fédérale de Lausanne)

  • S. Perdikis

    (École Polytechnique Fédérale de Lausanne
    Wyss Center for Bio and Neuroengineering)

  • A. Al-Khodairy

    (SUVACare - Clinique Romande de Réadaptation)

  • T. Corbet

    (École Polytechnique Fédérale de Lausanne)

  • A. Schnider

    (University Hospital of Geneva)

  • T. Schmidlin

    (École Polytechnique Fédérale de Lausanne)

  • H. Zhang

    (École Polytechnique Fédérale de Lausanne)

  • M. Bassolino

    (École Polytechnique Fédérale de Lausanne)

  • D. Viceic

    (École Polytechnique Fédérale de Lausanne)

  • P. Vuadens

    (SUVACare - Clinique Romande de Réadaptation)

  • A. G. Guggisberg

    (University Hospital of Geneva)

  • J. d. R. Millán

    (École Polytechnique Fédérale de Lausanne)

Abstract

Brain-computer interfaces (BCI) are used in stroke rehabilitation to translate brain signals into intended movements of the paralyzed limb. However, the efficacy and mechanisms of BCI-based therapies remain unclear. Here we show that BCI coupled to functional electrical stimulation (FES) elicits significant, clinically relevant, and lasting motor recovery in chronic stroke survivors more effectively than sham FES. Such recovery is associated to quantitative signatures of functional neuroplasticity. BCI patients exhibit a significant functional recovery after the intervention, which remains 6–12 months after the end of therapy. Electroencephalography analysis pinpoints significant differences in favor of the BCI group, mainly consisting in an increase in functional connectivity between motor areas in the affected hemisphere. This increase is significantly correlated with functional improvement. Results illustrate how a BCI–FES therapy can drive significant functional recovery and purposeful plasticity thanks to contingent activation of body natural efferent and afferent pathways.

Suggested Citation

  • A. Biasiucci & R. Leeb & I. Iturrate & S. Perdikis & A. Al-Khodairy & T. Corbet & A. Schnider & T. Schmidlin & H. Zhang & M. Bassolino & D. Viceic & P. Vuadens & A. G. Guggisberg & J. d. R. Millán, 2018. "Brain-actuated functional electrical stimulation elicits lasting arm motor recovery after stroke," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04673-z
    DOI: 10.1038/s41467-018-04673-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-04673-z
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-04673-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04673-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.