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Topologically frustrated dynamics of crowded charged macromolecules in charged hydrogels

Author

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  • Di Jia

    (University of Massachusetts)

  • Murugappan Muthukumar

    (University of Massachusetts)

Abstract

Movement of charged macromolecules in crowded aqueous environments is a ubiquitous phenomenon vital to the various living processes and formulations of materials for health care. While study of diffusion of tracer amounts of probe macromolecules trapped inside concentrated solutions, gels, or random media has led to an enhanced understanding of this complex process, the collective dynamics of charged macromolecules embedded inside congested charge-bearing matrices still remains to be fully explored. Here we report a frustrated dynamics of DNA and synthetic polyelectrolytes inside a charged host hydrogel where the guest molecules do not diffuse. Instead, they exhibit a family of relaxation processes arising from a combination of conformational entropy and local chain dynamics, which are frustrated by the confinement from the gel. We also have developed a model explaining this new universality class of non-diffusive topologically frustrated dynamics of charged macromolecules.

Suggested Citation

  • Di Jia & Murugappan Muthukumar, 2018. "Topologically frustrated dynamics of crowded charged macromolecules in charged hydrogels," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04661-3
    DOI: 10.1038/s41467-018-04661-3
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    Cited by:

    1. Binghui Xue & Yuan Liu & Ye Tian & Panchao Yin, 2024. "The coupling of rotational and translational dynamics for rapid diffusion of nanorods in macromolecular networks," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    2. Gui Kang Wang & Yi Ming Yang & Di Jia, 2024. "Programming viscoelastic properties in a complexation gel composite by utilizing entropy-driven topologically frustrated dynamical state," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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