IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-04594-x.html
   My bibliography  Save this article

Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces

Author

Listed:
  • Daniel Rodrigo

    (École Polytechnique Fédérale de Lausanne (EPFL)
    The Barcelona Institute of Science and Technology)

  • Andreas Tittl

    (École Polytechnique Fédérale de Lausanne (EPFL))

  • Nadine Ait-Bouziad

    (École Polytechnique Fédérale de Lausanne (EPFL))

  • Aurelian John-Herpin

    (École Polytechnique Fédérale de Lausanne (EPFL))

  • Odeta Limaj

    (École Polytechnique Fédérale de Lausanne (EPFL))

  • Christopher Kelly

    (École Polytechnique Fédérale de Lausanne (EPFL)
    University of Glasgow)

  • Daehan Yoo

    (University of Minnesota)

  • Nathan J. Wittenberg

    (University of Minnesota
    Lehigh University)

  • Sang-Hyun Oh

    (University of Minnesota)

  • Hilal A. Lashuel

    (École Polytechnique Fédérale de Lausanne (EPFL))

  • Hatice Altug

    (École Polytechnique Fédérale de Lausanne (EPFL))

Abstract

A multitude of biological processes are enabled by complex interactions between lipid membranes and proteins. To understand such dynamic processes, it is crucial to differentiate the constituent biomolecular species and track their individual time evolution without invasive labels. Here, we present a label-free mid-infrared biosensor capable of distinguishing multiple analytes in heterogeneous biological samples with high sensitivity. Our technology leverages a multi-resonant metasurface to simultaneously enhance the different vibrational fingerprints of multiple biomolecules. By providing up to 1000-fold near-field intensity enhancement over both amide and methylene bands, our sensor resolves the interactions of lipid membranes with different polypeptides in real time. Significantly, we demonstrate that our label-free chemically specific sensor can analyze peptide-induced neurotransmitter cargo release from synaptic vesicle mimics. Our sensor opens up exciting possibilities for gaining new insights into biological processes such as signaling or transport in basic research as well as provides a valuable toolkit for bioanalytical and pharmaceutical applications.

Suggested Citation

  • Daniel Rodrigo & Andreas Tittl & Nadine Ait-Bouziad & Aurelian John-Herpin & Odeta Limaj & Christopher Kelly & Daehan Yoo & Nathan J. Wittenberg & Sang-Hyun Oh & Hilal A. Lashuel & Hatice Altug, 2018. "Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces," Nature Communications, Nature, vol. 9(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04594-x
    DOI: 10.1038/s41467-018-04594-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-04594-x
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-04594-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Zhihao Ren & Zixuan Zhang & Jingxuan Wei & Bowei Dong & Chengkuo Lee, 2022. "Wavelength-multiplexed hook nanoantennas for machine learning enabled mid-infrared spectroscopy," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04594-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.