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Upconversion nanocomposite for programming combination cancer therapy by precise control of microscopic temperature

Author

Listed:
  • Xingjun Zhu

    (Fudan University)

  • Jiachang Li

    (Fudan University)

  • Xiaochen Qiu

    (Fudan University)

  • Yi Liu

    (Fudan University)

  • Wei Feng

    (Fudan University)

  • Fuyou Li

    (Fudan University)

Abstract

Combinational administration of chemotherapy (CT) and photothermal therapy (PTT) has been widely used to treat cancer. However, the scheduling of CT and PTT and how it will affect the therapeutic efficacy has not been thoroughly investigated. The challenge is to realize the sequence control of these two therapeutic modes. Herein, we design a temperature sensitive upconversion nanocomposite for CT-PTT combination therapy. By monitoring the microscopic temperature of the nanocomposite with upconversion luminescence, photothermal effect can be adjusted to achieve thermally triggered combination therapy with a sequence of CT, followed by PTT. We find that CT administered before PTT results in better therapeutic effect than other administration sequences when the dosages of chemodrug and heat are kept at the same level. This work proposes a programmed method to arrange the process of combination cancer therapy, which takes full advantage of each therapeutic mode and contributes to the development of new cancer therapy strategies.

Suggested Citation

  • Xingjun Zhu & Jiachang Li & Xiaochen Qiu & Yi Liu & Wei Feng & Fuyou Li, 2018. "Upconversion nanocomposite for programming combination cancer therapy by precise control of microscopic temperature," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04571-4
    DOI: 10.1038/s41467-018-04571-4
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    Cited by:

    1. Yukai Wu & Fang Li & Yanan Wu & Hao Wang & Liangtao Gu & Jieying Zhang & Yukun Qi & Lingkai Meng & Na Kong & Yingjie Chai & Qian Hu & Zhenyu Xing & Wuwei Ren & Fuyou Li & Xingjun Zhu, 2024. "Lanthanide luminescence nanothermometer with working wavelength beyond 1500 nm for cerebrovascular temperature imaging in vivo," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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