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The role of dynamic enzyme assemblies and substrate channelling in metabolic regulation

Author

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  • Lee J. Sweetlove

    (University of Oxford)

  • Alisdair R. Fernie

    (Max-Planck-Institut für Molekulare Pflanzenphysiologie)

Abstract

Transient physical association between enzymes appears to be a cardinal feature of metabolic systems, yet the purpose of this metabolic organisation remains enigmatic. It is generally assumed that substrate channelling occurs in these complexes. However, there is a lack of information concerning the mechanisms and extent of substrate channelling and confusion regarding the consequences of substrate channelling. In this review, we outline recent advances in the structural characterisation of enzyme assemblies and integrate this with new insights from reaction–diffusion modelling and synthetic biology to clarify the mechanistic and functional significance of the phenomenon.

Suggested Citation

  • Lee J. Sweetlove & Alisdair R. Fernie, 2018. "The role of dynamic enzyme assemblies and substrate channelling in metabolic regulation," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04543-8
    DOI: 10.1038/s41467-018-04543-8
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    Cited by:

    1. Weronika Jasinska & Mirco Dindo & Sandra M. C. Cordoba & Adrian W. R. Serohijos & Paola Laurino & Yariv Brotman & Shimon Bershtein, 2024. "Non-consecutive enzyme interactions within TCA cycle supramolecular assembly regulate carbon-nitrogen metabolism," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Joyce C. Breger & James N. Vranish & Eunkeu Oh & Michael H. Stewart & Kimihiro Susumu & Guillermo Lasarte-Aragonés & Gregory A. Ellis & Scott A. Walper & Sebastián A. Díaz & Shelby L. Hooe & William , 2023. "Self assembling nanoparticle enzyme clusters provide access to substrate channeling in multienzymatic cascades," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    3. Liangxiao Tan & Jun-Hao Zhou & Jian-Ke Sun & Jiayin Yuan, 2022. "Electrostatically cooperative host-in-host of metal cluster ⊂ ionic organic cages in nanopores for enhanced catalysis," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    4. Alastair G. Kerr & Zuoneng Wang & Na Wang & Kelvin H. M. Kwok & Jutta Jalkanen & Alison Ludzki & Simon Lecoutre & Dominique Langin & Martin O. Bergo & Ingrid Dahlman & Carsten Mim & Peter Arner & Hui , 2022. "The long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    5. György Abrusán & Aleksej Zelezniak, 2024. "Cellular location shapes quaternary structure of enzymes," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    6. Xixi Sun & Yujie Yuan & Qitong Chen & Shiqi Nie & Jiaxuan Guo & Zutian Ou & Min Huang & Zixin Deng & Tiangang Liu & Tian Ma, 2022. "Metabolic pathway assembly using docking domains from type I cis-AT polyketide synthases," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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