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MxB is an interferon-induced restriction factor of human herpesviruses

Author

Listed:
  • Michel Crameri

    (University of Zurich
    Life Science Zurich Graduate School)

  • Michael Bauer

    (Life Science Zurich Graduate School
    University of Zurich)

  • Nicole Caduff

    (Life Science Zurich Graduate School
    University of Zurich)

  • Raphael Walker

    (University of Zurich)

  • Fiona Steiner

    (University of Zurich
    Life Science Zurich Graduate School)

  • Francesca D. Franzoso

    (University of Zurich
    University Hospital Zurich)

  • Cornelia Gujer

    (University of Zurich)

  • Karin Boucke

    (University of Zurich)

  • Talissa Kucera

    (University of Zurich)

  • Andrea Zbinden

    (University of Zurich)

  • Christian Münz

    (University of Zurich)

  • Cornel Fraefel

    (University of Zurich)

  • Urs F. Greber

    (University of Zurich)

  • Jovan Pavlovic

    (University of Zurich)

Abstract

The type I interferon (IFN) system plays an important role in controlling herpesvirus infections, but it is unclear which IFN-mediated effectors interfere with herpesvirus replication. Here we report that human myxovirus resistance protein B (MxB, also designated Mx2) is a potent human herpesvirus restriction factor in the context of IFN. We demonstrate that ectopic MxB expression restricts a range of herpesviruses from the Alphaherpesvirinae and Gammaherpesvirinae, including herpes simplex virus 1 and 2 (HSV-1 and HSV-2), and Kaposi’s sarcoma-associated herpesvirus (KSHV). MxB restriction of HSV-1 and HSV-2 requires GTPase function, in contrast to restriction of lentiviruses. MxB inhibits the delivery of incoming HSV-1 DNA to the nucleus and the appearance of empty capsids, but not the capsid delivery to the cytoplasm or tegument dissociation from the capsid. Our study identifies MxB as a potent pan-herpesvirus restriction factor which blocks the uncoating of viral DNA from the incoming viral capsid.

Suggested Citation

  • Michel Crameri & Michael Bauer & Nicole Caduff & Raphael Walker & Fiona Steiner & Francesca D. Franzoso & Cornelia Gujer & Karin Boucke & Talissa Kucera & Andrea Zbinden & Christian Münz & Cornel Frae, 2018. "MxB is an interferon-induced restriction factor of human herpesviruses," Nature Communications, Nature, vol. 9(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04379-2
    DOI: 10.1038/s41467-018-04379-2
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