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Concurrent and orthogonal gold(I) and ruthenium(II) catalysis inside living cells

Author

Listed:
  • Cristian Vidal

    (Universidade de Santiago de Compostela)

  • María Tomás-Gamasa

    (Universidade de Santiago de Compostela)

  • Paolo Destito

    (Universidade de Santiago de Compostela)

  • Fernando López

    (Universidade de Santiago de Compostela
    Instituto de Química Orgánica General CSIC)

  • José L. Mascareñas

    (Universidade de Santiago de Compostela)

Abstract

The viability of building artificial metabolic pathways within a cell will depend on our ability to design biocompatible and orthogonal catalysts capable of achieving non-natural transformations. In this context, transition metal complexes offer unique possibilities to develop catalytic reactions that do not occur in nature. However, translating the potential of metal catalysts to living cells poses numerous challenges associated to their biocompatibility, and their stability and reactivity in crowded aqueous environments. Here we report a gold-mediated C–C bond formation that occurs in complex aqueous habitats, and demonstrate that the reaction can be translated to living mammalian cells. Key to the success of the process is the use of designed, water-activatable gold chloride complexes. Moreover, we demonstrate the viability of achieving the gold-promoted process in parallel with a ruthenium-mediated reaction, inside living cells, and in a bioorthogonal and mutually orthogonal manner.

Suggested Citation

  • Cristian Vidal & María Tomás-Gamasa & Paolo Destito & Fernando López & José L. Mascareñas, 2018. "Concurrent and orthogonal gold(I) and ruthenium(II) catalysis inside living cells," Nature Communications, Nature, vol. 9(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04314-5
    DOI: 10.1038/s41467-018-04314-5
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