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Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex

Author

Listed:
  • Tao Chen

    (Xi’an Jiaotong University
    The Fourth Military Medical University)

  • Wataru Taniguchi

    (Kansai University of Health Sciences, Kumatori
    Wakayama Medical University)

  • Qi-Yu Chen

    (Xi’an Jiaotong University)

  • Hidetoshi Tozaki-Saitoh

    (Kyushu University)

  • Qian Song

    (Xi’an Jiaotong University)

  • Ren-Hao Liu

    (Xi’an Jiaotong University)

  • Kohei Koga

    (Xi’an Jiaotong University
    Kyushu University)

  • Tsuyoshi Matsuda

    (Kyushu University)

  • Yae Kaito-Sugimura

    (Kansai University of Health Sciences, Kumatori)

  • Jian Wang

    (The Fourth Military Medical University)

  • Zhi-Hua Li

    (The Fourth Military Medical University)

  • Ya-Cheng Lu

    (The Fourth Military Medical University)

  • Kazuhide Inoue

    (Kyushu University)

  • Makoto Tsuda

    (Kyushu University)

  • Yun-Qing Li

    (The Fourth Military Medical University)

  • Terumasa Nakatsuka

    (Kansai University of Health Sciences, Kumatori)

  • Min Zhuo

    (Xi’an Jiaotong University
    University of Toronto)

Abstract

Spinal sensory transmission is under descending biphasic modulation, and descending facilitation is believed to contribute to chronic pain. Descending modulation from the brainstem rostral ventromedial medulla (RVM) has been the most studied, whereas little is known about direct corticospinal modulation. Here, we found that stimulation in the anterior cingulate cortex (ACC) potentiated spinal excitatory synaptic transmission and this modulation is independent of the RVM. Peripheral nerve injury enhanced the spinal synaptic transmission and occluded the ACC-spinal cord facilitation. Inhibition of ACC reduced the enhanced spinal synaptic transmission caused by nerve injury. Finally, using optogenetics, we showed that selective activation of ACC-spinal cord projecting neurons caused behavioral pain sensitization, while inhibiting the projection induced analgesic effects. Our results provide strong evidence that ACC stimulation facilitates spinal sensory excitatory transmission by a RVM-independent manner, and that such top-down facilitation may contribute to the process of chronic neuropathic pain.

Suggested Citation

  • Tao Chen & Wataru Taniguchi & Qi-Yu Chen & Hidetoshi Tozaki-Saitoh & Qian Song & Ren-Hao Liu & Kohei Koga & Tsuyoshi Matsuda & Yae Kaito-Sugimura & Jian Wang & Zhi-Hua Li & Ya-Cheng Lu & Kazuhide Inou, 2018. "Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex," Nature Communications, Nature, vol. 9(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04309-2
    DOI: 10.1038/s41467-018-04309-2
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    Cited by:

    1. Daniel G. Taub & Qiufen Jiang & Francesca Pietrafesa & Junfeng Su & Aloe Carroll & Caitlin Greene & Michael R. Blanchard & Aakanksha Jain & Mahmoud El-Rifai & Alexis Callen & Katherine Yager & Clara C, 2024. "The secondary somatosensory cortex gates mechanical and heat sensitivity," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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