IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-04295-5.html
   My bibliography  Save this article

Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages

Author

Listed:
  • Evelien M. Bunnik

    (The University of Texas Health Science Center at San Antonio
    University of California Riverside)

  • Kate B. Cook

    (University of Washington)

  • Nelle Varoquaux

    (University of California
    Berkeley Institute for Data Science
    MINES ParisTech, PSL Research University, CBIO-Centre for Computational Biology
    Institut Curie)

  • Gayani Batugedara

    (University of California Riverside)

  • Jacques Prudhomme

    (University of California Riverside)

  • Anthony Cort

    (University of California Riverside)

  • Lirong Shi

    (Johns Hopkins Bloomberg School of Public Health)

  • Chiara Andolina

    (University of Oxford, Old Road campus
    Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot)

  • Leila S. Ross

    (Columbia University Medical Center)

  • Declan Brady

    (Queens Medical Centre, University of Nottingham)

  • David A. Fidock

    (Columbia University Medical Center
    Columbia University)

  • Francois Nosten

    (University of Oxford, Old Road campus
    Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot)

  • Rita Tewari

    (Queens Medical Centre, University of Nottingham)

  • Photini Sinnis

    (Johns Hopkins Bloomberg School of Public Health)

  • Ferhat Ay

    (La Jolla Institute for Allergy & Immunology)

  • Jean-Philippe Vert

    (MINES ParisTech, PSL Research University, CBIO-Centre for Computational Biology
    Institut Curie
    U900, INSERM
    École normale supérieure, CNRS, PSL Research University)

  • William Stafford Noble

    (University of Washington
    University of Washington)

  • Karine G. Le Roch

    (University of California Riverside)

Abstract

The development of malaria parasites throughout their various life cycle stages is coordinated by changes in gene expression. We previously showed that the three-dimensional organization of the Plasmodium falciparum genome is strongly associated with gene expression during its replication cycle inside red blood cells. Here, we analyze genome organization in the P. falciparum and P. vivax transmission stages. Major changes occur in the localization and interactions of genes involved in pathogenesis and immune evasion, host cell invasion, sexual differentiation, and master regulation of gene expression. Furthermore, we observe reorganization of subtelomeric heterochromatin around genes involved in host cell remodeling. Depletion of heterochromatin protein 1 (PfHP1) resulted in loss of interactions between virulence genes, confirming that PfHP1 is essential for maintenance of the repressive center. Our results suggest that the three-dimensional genome structure of human malaria parasites is strongly connected with transcriptional activity of specific gene families throughout the life cycle.

Suggested Citation

  • Evelien M. Bunnik & Kate B. Cook & Nelle Varoquaux & Gayani Batugedara & Jacques Prudhomme & Anthony Cort & Lirong Shi & Chiara Andolina & Leila S. Ross & Declan Brady & David A. Fidock & Francois Nos, 2018. "Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04295-5
    DOI: 10.1038/s41467-018-04295-5
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-04295-5
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-04295-5?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04295-5. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.