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Myosin1D is an evolutionarily conserved regulator of animal left–right asymmetry

Author

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  • Thomas Juan

    (Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose)

  • Charles Géminard

    (Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose)

  • Jean-Baptiste Coutelis

    (Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose)

  • Delphine Cerezo

    (Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose)

  • Sophie Polès

    (Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose)

  • Stéphane Noselli

    (Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose)

  • Maximilian Fürthauer

    (Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose)

Abstract

The establishment of left–right (LR) asymmetry is fundamental to animal development, but the identification of a unifying mechanism establishing laterality across different phyla has remained elusive. A cilia-driven, directional fluid flow is important for symmetry breaking in numerous vertebrates, including zebrafish. Alternatively, LR asymmetry can be established independently of cilia, notably through the intrinsic chirality of the acto-myosin cytoskeleton. Here, we show that Myosin1D (Myo1D), a previously identified regulator of Drosophila LR asymmetry, is essential for the formation and function of the zebrafish LR organizer (LRO), Kupffer’s vesicle (KV). Myo1D controls the orientation of LRO cilia and interacts functionally with the planar cell polarity (PCP) pathway component VanGogh-like2 (Vangl2), to shape a productive LRO flow. Our findings identify Myo1D as an evolutionarily conserved regulator of animal LR asymmetry, and show that functional interactions between Myo1D and PCP are central to the establishment of animal LR asymmetry.

Suggested Citation

  • Thomas Juan & Charles Géminard & Jean-Baptiste Coutelis & Delphine Cerezo & Sophie Polès & Stéphane Noselli & Maximilian Fürthauer, 2018. "Myosin1D is an evolutionarily conserved regulator of animal left–right asymmetry," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04284-8
    DOI: 10.1038/s41467-018-04284-8
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    Cited by:

    1. Anshuman Sewda & A J Agopian & Elizabeth Goldmuntz & Hakon Hakonarson & Bernice E Morrow & Fadi Musfee & Deanne Taylor & Laura E Mitchell & on behalf of the Pediatric Cardiac Genomics Consortium, 2020. "Gene-based analyses of the maternal genome implicate maternal effect genes as risk factors for conotruncal heart defects," PLOS ONE, Public Library of Science, vol. 15(6), pages 1-15, June.

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