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Sema7A/PlxnCl signaling triggers activity-dependent olfactory synapse formation

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  • Nobuko Inoue

    (University of Fukui School of Medicine)

  • Hirofumi Nishizumi

    (University of Fukui School of Medicine)

  • Hiromi Naritsuka

    (The University of Tokyo)

  • Hiroshi Kiyonari

    (RIKEN Institute)

  • Hitoshi Sakano

    (University of Fukui School of Medicine)

Abstract

In mammals, neural circuits are formed based on a genetic program and further refined by neuronal activity during the neonatal period. We report that in the mouse olfactory system, the glomerular map is not merely refined but newly connected to second-order neurons by odorant-receptor-derived neuronal activity. Here, we analyzed a pair of molecules, Sema7A, expressed in olfactory sensory neurons (OSNs) in an activity-dependent manner, and PlxnC1, localized to dendrites of mitral/tufted (M/T) cells in the first week after birth. In Sema7A or PlxnC1 knockout (KO) mice, initiation of synapse formation and dendrite selection of M/T cells were perturbed. Reconstitution and rescue experiments demonstrated that Sema7A–PlxnC1 interaction is essential to form the post-synaptic assembly. Pharmacological blocking experiments indicated that synaptic transmission triggers primary dendrite selection by synaptic competition. We conclude that Sema7A signaling is key to inducing activity-dependent post-synapse events and dendrite selection in M/T-cells during the neonatal period.

Suggested Citation

  • Nobuko Inoue & Hirofumi Nishizumi & Hiromi Naritsuka & Hiroshi Kiyonari & Hitoshi Sakano, 2018. "Sema7A/PlxnCl signaling triggers activity-dependent olfactory synapse formation," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04239-z
    DOI: 10.1038/s41467-018-04239-z
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