IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-04148-1.html
   My bibliography  Save this article

Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system

Author

Listed:
  • Julia Ramírez

    (Queen Mary University of London
    University College London)

  • Stefan van Duijvenboden

    (Queen Mary University of London
    University College London)

  • Ioanna Ntalla

    (Queen Mary University of London)

  • Borbala Mifsud

    (Queen Mary University of London
    Queen Mary University of London)

  • Helen R Warren

    (Queen Mary University of London
    Queen Mary University of London)

  • Evan Tzanis

    (Queen Mary University of London
    Queen Mary University of London)

  • Michele Orini

    (St Bartholomews Hospital
    University College London)

  • Andrew Tinker

    (Queen Mary University of London
    Queen Mary University of London)

  • Pier D. Lambiase

    (University College London
    St Bartholomews Hospital)

  • Patricia B. Munroe

    (Queen Mary University of London
    Queen Mary University of London)

Abstract

Impaired capacity to increase heart rate (HR) during exercise (ΔHRex), and a reduced rate of recovery post-exercise (ΔHRrec) are associated with higher cardiovascular mortality rates. Currently, the genetic basis of both phenotypes remains to be elucidated. We conduct genome-wide association studies (GWASs) for ΔHRex and ΔHRrec in ~40,000 individuals, followed by replication in ~27,000 independent samples, all from UK Biobank. Six and seven single-nucleotide polymorphisms for ΔHRex and ΔHRrec, respectively, formally replicate. In a full data set GWAS, eight further loci for ΔHRex and nine for ΔHRrec are genome-wide significant (P ≤ 5 × 10−8). In total, 30 loci are discovered, 8 being common across traits. Processes of neural development and modulation of adrenergic activity by the autonomic nervous system are enriched in these results. Our findings reinforce current understanding of HR response to exercise and recovery and could guide future studies evaluating its contribution to cardiovascular risk prediction.

Suggested Citation

  • Julia Ramírez & Stefan van Duijvenboden & Ioanna Ntalla & Borbala Mifsud & Helen R Warren & Evan Tzanis & Michele Orini & Andrew Tinker & Pier D. Lambiase & Patricia B. Munroe, 2018. "Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04148-1
    DOI: 10.1038/s41467-018-04148-1
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-04148-1
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-04148-1?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04148-1. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.