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Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure

Author

Listed:
  • Alessia Visconti

    (King’s College London)

  • David L. Duffy

    (QIMR Berghofer Medical Research Institute)

  • Fan Liu

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Erasmus MC University Medical Center Rotterdam)

  • Gu Zhu

    (QIMR Berghofer Medical Research Institute)

  • Wenting Wu

    (Indiana University)

  • Yan Chen

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Pirro G. Hysi

    (King’s College London)

  • Changqing Zeng

    (Chinese Academy of Sciences)

  • Marianna Sanna

    (King’s College London)

  • Mark M. Iles

    (University of Leeds)

  • Peter A. Kanetsky

    (H. Lee Moffitt Cancer Center and Research Institute)

  • Florence Demenais

    (Genetic Variation and Human Diseases Unit
    Sorbonne Paris Cité)

  • Merel A. Hamer

    (Erasmus MC University Medical Center Rotterdam)

  • Andre G. Uitterlinden

    (Erasmus MC University Medical Center Rotterdam
    Erasmus MC University Medical Center Rotterdam)

  • M. Arfan Ikram

    (Erasmus MC University Medical Center Rotterdam)

  • Tamar Nijsten

    (Erasmus MC University Medical Center Rotterdam)

  • Nicholas G. Martin

    (QIMR Berghofer Medical Research Institute)

  • Manfred Kayser

    (Erasmus MC University Medical Center Rotterdam)

  • Tim D. Spector

    (King’s College London)

  • Jiali Han

    (Indiana University
    Brigham and Women’s Hospital)

  • Veronique Bataille

    (King’s College London
    West Herts NHS Trust)

  • Mario Falchi

    (King’s College London)

Abstract

The skin’s tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin tanning in 176,678 subjects of European ancestry. We identify significant association with tanning ability at 20 loci. We confirm previously identified associations at six of these loci, and report 14 novel loci, of which ten have never been associated with pigmentation-related phenotypes. Our results also suggest that variants at the AHR/AGR3 locus, previously associated with cutaneous malignant melanoma the underlying mechanism of which is poorly understood, might act on disease risk through modulation of tanning ability.

Suggested Citation

  • Alessia Visconti & David L. Duffy & Fan Liu & Gu Zhu & Wenting Wu & Yan Chen & Pirro G. Hysi & Changqing Zeng & Marianna Sanna & Mark M. Iles & Peter A. Kanetsky & Florence Demenais & Merel A. Hamer &, 2018. "Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure," Nature Communications, Nature, vol. 9(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04086-y
    DOI: 10.1038/s41467-018-04086-y
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    Cited by:

    1. Beomsu Kim & Dan Say Kim & Joong-Gon Shin & Sangseob Leem & Minyoung Cho & Hanji Kim & Ki-Nam Gu & Jung Yeon Seo & Seung Won You & Alicia R. Martin & Sun Gyoo Park & Yunkwan Kim & Choongwon Jeong & Na, 2024. "Mapping and annotating genomic loci to prioritize genes and implicate distinct polygenic adaptations for skin color," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. James J. Gilchrist & Seiko Makino & Vivek Naranbhai & Piyush K. Sharma & Surya Koturan & Orion Tong & Chelsea A. Taylor & Robert A. Watson & Alba Verge los Aires & Rosalin Cooper & Evelyn Lau & Sara D, 2022. "Natural Killer cells demonstrate distinct eQTL and transcriptome-wide disease associations, highlighting their role in autoimmunity," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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