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Exercise induces new cardiomyocyte generation in the adult mammalian heart

Author

Listed:
  • Ana Vujic

    (Harvard University)

  • Carolin Lerchenmüller

    (Cardiology Division and Corrigan Minehan Heart Center
    Harvard Medical School)

  • Ting-Di Wu

    (Institut Curie, PSL Research University
    Université Paris-Saclay)

  • Christelle Guillermier

    (Harvard Medical School
    Brigham and Women’s Hospital
    Brigham and Women’s Hospital)

  • Charles P. Rabolli

    (Cardiology Division and Corrigan Minehan Heart Center)

  • Emilia Gonzalez

    (Harvard University)

  • Samuel E. Senyo

    (Case Western Reserve University)

  • Xiaojun Liu

    (Cardiology Division and Corrigan Minehan Heart Center
    Harvard Medical School)

  • Jean-Luc Guerquin-Kern

    (Institut Curie, PSL Research University
    Université Paris-Saclay)

  • Matthew L. Steinhauser

    (Harvard Medical School
    Brigham and Women’s Hospital
    Brigham and Women’s Hospital
    Brigham and Women’s Hospital)

  • Richard T. Lee

    (Harvard University)

  • Anthony Rosenzweig

    (Cardiology Division and Corrigan Minehan Heart Center
    Harvard Medical School)

Abstract

Loss of cardiomyocytes is a major cause of heart failure, and while the adult heart has a limited capacity for cardiomyogenesis, little is known about what regulates this ability or whether it can be effectively harnessed. Here we show that 8 weeks of running exercise increase birth of new cardiomyocytes in adult mice (~4.6-fold). New cardiomyocytes are identified based on incorporation of 15N-thymidine by multi-isotope imaging mass spectrometry (MIMS) and on being mononucleate/diploid. Furthermore, we demonstrate that exercise after myocardial infarction induces a robust cardiomyogenic response in an extended border zone of the infarcted area. Inhibition of miR-222, a microRNA increased by exercise in both animal models and humans, completely blocks the cardiomyogenic exercise response. These findings demonstrate that cardiomyogenesis can be activated by exercise in the normal and injured adult mouse heart and suggest that stimulation of endogenous cardiomyocyte generation could contribute to the benefits of exercise.

Suggested Citation

  • Ana Vujic & Carolin Lerchenmüller & Ting-Di Wu & Christelle Guillermier & Charles P. Rabolli & Emilia Gonzalez & Samuel E. Senyo & Xiaojun Liu & Jean-Luc Guerquin-Kern & Matthew L. Steinhauser & Richa, 2018. "Exercise induces new cardiomyocyte generation in the adult mammalian heart," Nature Communications, Nature, vol. 9(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04083-1
    DOI: 10.1038/s41467-018-04083-1
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