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Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity

Author

Listed:
  • Wooseong Lee

    (Yonsei University)

  • Seung-Hoon Lee

    (Yonsei University)

  • Minwoo Kim

    (Yonsei University)

  • Jae-Su Moon

    (Yonsei University)

  • Geon-Woo Kim

    (Yonsei University)

  • Hae-Gwang Jung

    (Yonsei University)

  • In Hwang Kim

    (Sogang University)

  • Ji Eun Oh

    (Korea Advanced Institute of Science and Technology (KAIST))

  • Hi Eun Jung

    (Korea Advanced Institute of Science and Technology (KAIST))

  • Heung Kyu Lee

    (Korea Advanced Institute of Science and Technology (KAIST)
    Korea Advanced Institute of Science and Technology (KAIST))

  • Keun Bon Ku

    (Korea Research Institute of Chemical Technology)

  • Dae-Gyun Ahn

    (Korea Research Institute of Chemical Technology)

  • Seong-Jun Kim

    (Korea Research Institute of Chemical Technology)

  • Kun-Soo Kim

    (Sogang University)

  • Jong-Won Oh

    (Yonsei University)

Abstract

The recognition of pathogen-derived ligands by pattern recognition receptors activates the innate immune response, but the potential interaction of quorum-sensing (QS) signaling molecules with host anti-viral defenses remains largely unknown. Here we show that the Vibrio vulnificus QS molecule cyclo(Phe-Pro) (cFP) inhibits interferon (IFN)-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation. Binding of cFP to the RIG-I 2CARD domain induces a conformational change in RIG-I, preventing the TRIM25-mediated ubiquitination to abrogate IFN production. cFP enhances susceptibility to hepatitis C virus (HCV), as well as Sendai and influenza viruses, each known to be sensed by RIG-I but did not affect the melanoma-differentiation-associated gene 5 (MDA5)-recognition of norovirus. Our results reveal an inter-kingdom network between bacteria, viruses and host that dysregulates host innate responses via a microbial quorum-sensing molecule modulating the response to viral infection.

Suggested Citation

  • Wooseong Lee & Seung-Hoon Lee & Minwoo Kim & Jae-Su Moon & Geon-Woo Kim & Hae-Gwang Jung & In Hwang Kim & Ji Eun Oh & Hi Eun Jung & Heung Kyu Lee & Keun Bon Ku & Dae-Gyun Ahn & Seong-Jun Kim & Kun-Soo, 2018. "Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04075-1
    DOI: 10.1038/s41467-018-04075-1
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