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A B-ARR-mediated cytokinin transcriptional network directs hormone cross-regulation and shoot development

Author

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  • Mingtang Xie

    (The Salk Institute for Biological Studies
    The Salk Institute for Biological Studies)

  • Hongyu Chen

    (Dartmouth College)

  • Ling Huang

    (The Salk Institute for Biological Studies)

  • Ryan C. O’Neil

    (The Salk Institute for Biological Studies
    University of California at San Diego)

  • Maxim N. Shokhirev

    (The Salk Institute for Biological Studies)

  • Joseph R. Ecker

    (The Salk Institute for Biological Studies
    The Salk Institute for Biological Studies)

Abstract

Cytokinin fulfills its diverse roles in planta through a series of transcriptional responses. We identify the in vivo DNA binding site profiles for three genetically redundant type-B ARABIDOPSIS RESPONSE REGULATORS (B-ARRs): ARR1, ARR10, and ARR12. The expression and genome-wide DNA binding locations of the three B-ARRs extensively overlap. Constructing a primary cytokinin response transcriptional network reveals a recurring theme of widespread cross-regulation between the components of the cytokinin pathway and other plant hormone pathways. The B-ARRs are found to have similar DNA binding motifs, though sequences flanking the core motif were degenerate. Cytokinin treatments amalgamate the three different B-ARRs motifs to identical DNA binding signatures (AGATHY, H(a/t/c), Y(t/c)) which suggests cytokinin may regulate binding activity of B-ARR family members. Furthermore, we find that WUSCHEL, a key gene required for apical meristem maintenance, is a cytokinin-dependent B-ARR target gene, demonstrating the importance of the cytokinin transcription factor network in shoot development.

Suggested Citation

  • Mingtang Xie & Hongyu Chen & Ling Huang & Ryan C. O’Neil & Maxim N. Shokhirev & Joseph R. Ecker, 2018. "A B-ARR-mediated cytokinin transcriptional network directs hormone cross-regulation and shoot development," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03921-6
    DOI: 10.1038/s41467-018-03921-6
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    Cited by:

    1. Pierre Gautrat & Sara Buti & Andrés Romanowski & Michiel Lammers & Sanne E. A. Matton & Guido Buijs & Ronald Pierik, 2024. "Phytochrome-dependent responsiveness to root-derived cytokinins enables coordinated elongation responses to combined light and nitrate cues," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Jiahuan Chen & Zhijuan Wang & Lixiang Wang & Yangyang Hu & Qiqi Yan & Jingjing Lu & Ziyin Ren & Yujie Hong & Hongtao Ji & Hui Wang & Xinying Wu & Yanru Lin & Chao Su & Thomas Ott & Xia Li, 2022. "The B-type response regulator GmRR11d mediates systemic inhibition of symbiotic nodulation," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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