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Competition between microtubule-associated proteins directs motor transport

Author

Listed:
  • Brigette Y. Monroy

    (University of California, Davis)

  • Danielle L. Sawyer

    (University of California, Davis)

  • Bryce E. Ackermann

    (University of California, Davis)

  • Melissa M. Borden

    (University of California, Davis)

  • Tracy C. Tan

    (University of California, Davis)

  • Kassandra M. Ori-McKenney

    (University of California, Davis)

Abstract

Within cells, motor and non-motor microtubule-associated proteins (MAPs) simultaneously converge on the microtubule. How the binding activities of non-motor MAPs are coordinated and how they contribute to the balance and distribution of motor transport is unknown. Here, we examine the relationship between MAP7 and tau owing to their antagonistic roles in vivo. We find that MAP7 and tau compete for binding to microtubules, and determine a mechanism by which MAP7 displaces tau from the lattice. MAP7 promotes kinesin-based transport in vivo and strongly recruits kinesin-1 to the microtubule in vitro, providing evidence for direct enhancement of motor motility by a MAP. Both MAP7 and tau strongly inhibit kinesin-3 and have no effect on cytoplasmic dynein, demonstrating that MAPs differentially control distinct classes of motors. Overall, these results reveal a general principle for how MAP competition dictates access to the microtubule to determine the correct distribution and balance of motor activity.

Suggested Citation

  • Brigette Y. Monroy & Danielle L. Sawyer & Bryce E. Ackermann & Melissa M. Borden & Tracy C. Tan & Kassandra M. Ori-McKenney, 2018. "Competition between microtubule-associated proteins directs motor transport," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03909-2
    DOI: 10.1038/s41467-018-03909-2
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    Cited by:

    1. Agnes Adler & Mamata Bangera & J. Wouter Beugelink & Salima Bahri & Hugo Ingen & Carolyn A. Moores & Marc Baldus, 2024. "A structural and dynamic visualization of the interaction between MAP7 and microtubules," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Ashwin I. D’Souza & Rahul Grover & Gina A. Monzon & Ludger Santen & Stefan Diez, 2023. "Vesicles driven by dynein and kinesin exhibit directional reversals without regulators," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Mireia Andreu-Carbó & Cornelia Egoldt & Marie-Claire Velluz & Charlotte Aumeier, 2024. "Microtubule damage shapes the acetylation gradient," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    4. John T. Canty & Andrew Hensley & Merve Aslan & Amanda Jack & Ahmet Yildiz, 2023. "TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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