IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-03836-2.html
   My bibliography  Save this article

Placental miR-340 mediates vulnerability to activity based anorexia in mice

Author

Listed:
  • Mariana Schroeder

    (Weizmann Institute of Science
    Max Planck Institute of Psychiatry)

  • Mira Jakovcevski

    (Max Planck Institute of Psychiatry)

  • Tamar Polacheck

    (Weizmann Institute of Science
    Max Planck Institute of Psychiatry)

  • Yonat Drori

    (Weizmann Institute of Science
    Max Planck Institute of Psychiatry)

  • Alessia Luoni

    (Max Planck Institute of Psychiatry)

  • Simone Röh

    (Max Planck Institute of Psychiatry)

  • Jonas Zaugg

    (University of Bern
    University of Bern)

  • Shifra Ben-Dor

    (Weizmann Institute of Science)

  • Christiane Albrecht

    (University of Bern
    University of Bern)

  • Alon Chen

    (Weizmann Institute of Science
    Max Planck Institute of Psychiatry)

Abstract

Anorexia nervosa (AN) is a devastating eating disorder characterized by self-starvation that mainly affects women. Its etiology is unknown, which impedes successful treatment options leading to a limited chance of full recovery. Here, we show that gestation is a vulnerable window that can influence the predisposition to AN. By screening placental microRNA expression of naive and prenatally stressed (PNS) fetuses and assessing vulnerability to activity-based anorexia (ABA), we identify miR-340 as a sexually dimorphic regulator involved in prenatal programming of ABA. PNS caused gene-body hypermethylation of placental miR-340, which is associated with reduced miR-340 expression and increased protein levels of several target transcripts, GR, Cry2 and H3F3b. MiR-340 is linked to the expression of several nutrient transporters both in mice and human placentas. Using placenta-specific lentiviral transgenes and embryo transfer, we demonstrate the key role miR-340 plays in the mechanism involved in early life programming of ABA.

Suggested Citation

  • Mariana Schroeder & Mira Jakovcevski & Tamar Polacheck & Yonat Drori & Alessia Luoni & Simone Röh & Jonas Zaugg & Shifra Ben-Dor & Christiane Albrecht & Alon Chen, 2018. "Placental miR-340 mediates vulnerability to activity based anorexia in mice," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03836-2
    DOI: 10.1038/s41467-018-03836-2
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-03836-2
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-03836-2?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03836-2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.