Author
Listed:
- Angela M. Early
(Broad Institute of MIT and Harvard
Harvard T.H. Chan School of Public Health)
- Marc Lievens
(GSK Vaccines)
- Bronwyn L. MacInnis
(Broad Institute of MIT and Harvard
Harvard T.H. Chan School of Public Health)
- Christian F. Ockenhouse
(PATH Malaria Vaccine Initiative)
- Sarah K. Volkman
(Broad Institute of MIT and Harvard
Harvard T.H. Chan School of Public Health
School of Nursing and Health Sciences)
- Samuel Adjei
(Kwame Nkrumah University of Science and Technology)
- Tsiri Agbenyega
(Kwame Nkrumah University of Science and Technology)
- Daniel Ansong
(Kwame Nkrumah University of Science and Technology)
- Stacey Gondi
(KEMRI–Walter Reed Project)
- Brian Greenwood
(London School of Hygiene and Tropical Medicine)
- Mary Hamel
(KEMRI/CDC Research and Public Health Collaboration)
- Chris Odero
(KEMRI/CDC Research and Public Health Collaboration)
- Kephas Otieno
(KEMRI/CDC Research and Public Health Collaboration)
- Walter Otieno
(KEMRI–Walter Reed Project)
- Seth Owusu-Agyei
(London School of Hygiene and Tropical Medicine
Kintampo Health Research Centre
University of Health and Allied Science)
- Kwaku Poku Asante
(Kintampo Health Research Centre)
- Hermann Sorgho
(Nanoro, Burkina Faso/Institute of Tropical Medicine)
- Lucas Tina
(KEMRI–Walter Reed Project)
- Halidou Tinto
(Nanoro, Burkina Faso/Institute of Tropical Medicine)
- Innocent Valea
(Nanoro, Burkina Faso/Institute of Tropical Medicine)
- Dyann F. Wirth
(Broad Institute of MIT and Harvard
Harvard T.H. Chan School of Public Health)
- Daniel E. Neafsey
(Broad Institute of MIT and Harvard
Harvard T.H. Chan School of Public Health)
Abstract
Host immunity exerts strong selective pressure on pathogens. Population-level genetic analysis can identify signatures of this selection, but these signatures reflect the net selective effect of all hosts and vectors in a population. In contrast, analysis of pathogen diversity within hosts provides information on individual, host-specific selection pressures. Here, we combine these complementary approaches in an analysis of the malaria parasite Plasmodium falciparum using haplotype sequences from thousands of natural infections in sub-Saharan Africa. We find that parasite genotypes show preferential clustering within multi-strain infections in young children, and identify individual amino acid positions that may contribute to strain-specific immunity. Our results demonstrate that natural host defenses to P. falciparum act in an allele-specific manner to block specific parasite haplotypes from establishing blood-stage infections. This selection partially explains the extreme amino acid diversity of many parasite antigens and suggests that vaccines targeting such proteins should account for allele-specific immunity.
Suggested Citation
Angela M. Early & Marc Lievens & Bronwyn L. MacInnis & Christian F. Ockenhouse & Sarah K. Volkman & Samuel Adjei & Tsiri Agbenyega & Daniel Ansong & Stacey Gondi & Brian Greenwood & Mary Hamel & Chris, 2018.
"Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections,"
Nature Communications, Nature, vol. 9(1), pages 1-10, December.
Handle:
RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03807-7
DOI: 10.1038/s41467-018-03807-7
Download full text from publisher
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03807-7. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
We have no bibliographic references for this item. You can help adding them by using this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .
Please note that corrections may take a couple of weeks to filter through
the various RePEc services.