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Synaptically silent sensory hair cells in zebrafish are recruited after damage

Author

Listed:
  • Qiuxiang Zhang

    (NIDCD/National Institutes of Health)

  • Suna Li

    (NIDCD/National Institutes of Health)

  • Hiu-Tung C. Wong

    (NIDCD/National Institutes of Health)

  • Xinyi J. He

    (NIDCD/National Institutes of Health)

  • Alisha Beirl

    (NIDCD/National Institutes of Health)

  • Ronald S. Petralia

    (NIDCD/National Institutes of Health)

  • Ya-Xian Wang

    (NIDCD/National Institutes of Health)

  • Katie S. Kindt

    (NIDCD/National Institutes of Health)

Abstract

Analysis of mechanotransduction among ensembles of sensory hair cells in vivo is challenging in many species. To overcome this challenge, we used optical indicators to investigate mechanotransduction among collections of hair cells in intact zebrafish. Our imaging reveals a previously undiscovered disconnect between hair-cell mechanosensation and synaptic transmission. We show that saturating mechanical stimuli able to open mechanically gated channels are unexpectedly insufficient to evoke vesicle fusion in the majority of hair cells. Although synaptically silent, latent hair cells can be rapidly recruited after damage, demonstrating that they are synaptically competent. Therefore synaptically silent hair cells may be an important reserve that acts to maintain sensory function. Our results demonstrate a previously unidentified level of complexity in sculpting sensory transmission from the periphery.

Suggested Citation

  • Qiuxiang Zhang & Suna Li & Hiu-Tung C. Wong & Xinyi J. He & Alisha Beirl & Ronald S. Petralia & Ya-Xian Wang & Katie S. Kindt, 2018. "Synaptically silent sensory hair cells in zebrafish are recruited after damage," Nature Communications, Nature, vol. 9(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03806-8
    DOI: 10.1038/s41467-018-03806-8
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    Cited by:

    1. Masashi Tanimoto & Ikuko Watakabe & Shin-ichi Higashijima, 2022. "Tiltable objective microscope visualizes selectivity for head motion direction and dynamics in zebrafish vestibular system," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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