IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-03796-7.html
   My bibliography  Save this article

TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis

Author

Listed:
  • Chunmei Wang

    (Baylor College of Medicine)

  • Yanlin He

    (Baylor College of Medicine)

  • Pingwen Xu

    (Baylor College of Medicine)

  • Yongjie Yang

    (Baylor College of Medicine)

  • Kenji Saito

    (Baylor College of Medicine)

  • Yan Xia

    (Baylor College of Medicine)

  • Xiaofeng Yan

    (Baylor College of Medicine)

  • Antentor Hinton Jr

    (Baylor College of Medicine)

  • Chunling Yan

    (Baylor College of Medicine)

  • Hongfang Ding

    (Baylor College of Medicine)

  • Likai Yu

    (Baylor College of Medicine)

  • Gang Shu

    (Baylor College of Medicine)

  • Rajat Gupta

    (Baylor College of Medicine)

  • Qi Wu

    (Baylor College of Medicine)

  • Qingchun Tong

    (University of Texas Health Science Center at Houston)

  • William R. Lagor

    (Baylor College of Medicine)

  • Elsa R. Flores

    (H. Lee Moffitt Cancer Center)

  • Yong Xu

    (Baylor College of Medicine
    Baylor College of Medicine)

Abstract

Sexual dimorphism exists in energy balance, but the underlying mechanisms remain unclear. Here we show that the female mice have more pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of hypothalamus than males, and female POMC neurons display higher neural activities, compared to male counterparts. Strikingly, deletion of the transcription factor, TAp63, in POMC neurons confers “male-like” diet-induced obesity (DIO) in female mice associated with decreased POMC neural activities; but the same deletion does not affect male mice. Our results indicate that TAp63 in female POMC neurons contributes to the enhanced POMC neuron functions and resistance to obesity in females. Thus, TAp63 in POMC neurons is one key molecular driver for the sexual dimorphism in energy homeostasis.

Suggested Citation

  • Chunmei Wang & Yanlin He & Pingwen Xu & Yongjie Yang & Kenji Saito & Yan Xia & Xiaofeng Yan & Antentor Hinton Jr & Chunling Yan & Hongfang Ding & Likai Yu & Gang Shu & Rajat Gupta & Qi Wu & Qingchun T, 2018. "TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03796-7
    DOI: 10.1038/s41467-018-03796-7
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-03796-7
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-03796-7?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Aibo Gao & Junlei Su & Ruixin Liu & Shaoqian Zhao & Wen Li & Xiaoqiang Xu & Danjie Li & Juan Shi & Bin Gu & Juan Zhang & Qi Li & Xiaolin Wang & Yifei Zhang & Yu Xu & Jieli Lu & Guang Ning & Jie Hong &, 2021. "Sexual dimorphism in glucose metabolism is shaped by androgen-driven gut microbiome," Nature Communications, Nature, vol. 12(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03796-7. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.