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Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury

Author

Listed:
  • Elena Lazzeri

    (University of Florence
    Transfer and High Education for the development of DE NOVO Therapies (DENOTHE))

  • Maria Lucia Angelotti

    (University of Florence
    Transfer and High Education for the development of DE NOVO Therapies (DENOTHE))

  • Anna Peired

    (University of Florence
    Transfer and High Education for the development of DE NOVO Therapies (DENOTHE))

  • Carolina Conte

    (University of Florence
    Transfer and High Education for the development of DE NOVO Therapies (DENOTHE))

  • Julian A. Marschner

    (Klinikum der LMU München)

  • Laura Maggi

    (Transfer and High Education for the development of DE NOVO Therapies (DENOTHE))

  • Benedetta Mazzinghi

    (Nephrology Unit and Meyer Children’s University Hospital)

  • Duccio Lombardi

    (University of Florence
    Transfer and High Education for the development of DE NOVO Therapies (DENOTHE))

  • Maria Elena Melica

    (University of Florence)

  • Sara Nardi

    (University of Florence
    Transfer and High Education for the development of DE NOVO Therapies (DENOTHE))

  • Elisa Ronconi

    (University of Florence
    Transfer and High Education for the development of DE NOVO Therapies (DENOTHE))

  • Alessandro Sisti

    (University of Florence
    Nephrology Unit and Meyer Children’s University Hospital)

  • Giulia Antonelli

    (University of Florence
    Transfer and High Education for the development of DE NOVO Therapies (DENOTHE))

  • Francesca Becherucci

    (Nephrology Unit and Meyer Children’s University Hospital)

  • Letizia Chiara

    (Nephrology Unit and Meyer Children’s University Hospital)

  • Ricardo Romero Guevara

    (University of Florence
    Transfer and High Education for the development of DE NOVO Therapies (DENOTHE))

  • Alexa Burger

    (University of Zurich)

  • Beat Schaefer

    (University Children’s Hospital)

  • Francesco Annunziato

    (Transfer and High Education for the development of DE NOVO Therapies (DENOTHE))

  • Hans-Joachim Anders

    (Klinikum der LMU München)

  • Laura Lasagni

    (University of Florence
    Transfer and High Education for the development of DE NOVO Therapies (DENOTHE))

  • Paola Romagnani

    (University of Florence
    Transfer and High Education for the development of DE NOVO Therapies (DENOTHE)
    Nephrology Unit and Meyer Children’s University Hospital)

Abstract

Acute kidney injury (AKI) is considered largely reversible based on the capacity of surviving tubular cells to dedifferentiate and replace lost cells via cell division. Here we show by tracking individual tubular cells in conditional Pax8/Confetti mice that kidney function is recovered after AKI despite substantial tubular cell loss. Cell cycle and ploidy analysis upon AKI in conditional Pax8/FUCCI2aR mice and human biopsies identify endocycle-mediated hypertrophy of tubular cells. By contrast, a small subset of Pax2+ tubular progenitors enriches via higher stress resistance and clonal expansion and regenerates necrotic tubule segments, a process that can be enhanced by suitable drugs. Thus, renal functional recovery upon AKI involves remnant tubular cell hypertrophy via endocycle and limited progenitor-driven regeneration that can be pharmacologically enhanced.

Suggested Citation

  • Elena Lazzeri & Maria Lucia Angelotti & Anna Peired & Carolina Conte & Julian A. Marschner & Laura Maggi & Benedetta Mazzinghi & Duccio Lombardi & Maria Elena Melica & Sara Nardi & Elisa Ronconi & Ale, 2018. "Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury," Nature Communications, Nature, vol. 9(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03753-4
    DOI: 10.1038/s41467-018-03753-4
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    Cited by:

    1. Moh’d Mohanad Al-Dabet & Khurrum Shahzad & Ahmed Elwakiel & Alba Sulaj & Stefan Kopf & Fabian Bock & Ihsan Gadi & Silke Zimmermann & Rajiv Rana & Shruthi Krishnan & Dheerendra Gupta & Jayakumar Manoha, 2022. "Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Rut Molinuevo & Julien Menendez & Kora Cadle & Nabeela Ariqat & Marie Klaire Choy & Cayla Lagousis & Gwen Thomas & Catherine Strietzel & J. W. Bubolz & Lindsay Hinck, 2024. "Physiological DNA damage promotes functional endoreplication of mammary gland alveolar cells during lactation," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    3. Letizia Chiara & Carolina Conte & Roberto Semeraro & Paula Diaz-Bulnes & Maria Lucia Angelotti & Benedetta Mazzinghi & Alice Molli & Giulia Antonelli & Samuela Landini & Maria Elena Melica & Anna Juli, 2022. "Tubular cell polyploidy protects from lethal acute kidney injury but promotes consequent chronic kidney disease," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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