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IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE

Author

Listed:
  • Shu Wang

    (MedImmune LLC)

  • Jingya Wang

    (MedImmune LLC)

  • Varsha Kumar

    (MedImmune LLC)

  • Jodi L. Karnell

    (MedImmune LLC
    Viela Bio)

  • Brian Naiman

    (MedImmune LLC)

  • Phillip S. Gross

    (MedImmune LLC)

  • Saifur Rahman

    (MedImmune LLC)

  • Kamelia Zerrouki

    (MedImmune LLC)

  • Richard Hanna

    (MedImmune LLC)

  • Christopher Morehouse

    (MedImmune LLC)

  • Nicholas Holoweckyj

    (MedImmune LLC)

  • Hao Liu

    (MedImmune LLC)

  • Zerai Manna

    (National Institutes of Health)

  • Raphaela Goldbach-Mansky

    (National Institutes of Health)

  • Sarfaraz Hasni

    (National Institutes of Health)

  • Richard Siegel

    (National Institutes of Health)

  • Miguel Sanjuan

    (MedImmune LLC
    Bristol-Myers Squibb)

  • Katie Streicher

    (MedImmune LLC)

  • Michael P. Cancro

    (University of Pennsylvania)

  • Roland Kolbeck

    (MedImmune LLC)

  • Rachel Ettinger

    (MedImmune LLC
    Viela Bio)

Abstract

Although the aetiology of systemic lupus erythematosus (SLE) is unclear, dysregulated B cell responses have been implicated. Here we show that an unusual CD11chiT-bet+ B cell subset, with a unique expression profile including chemokine receptors consistent with migration to target tissues, is expanded in SLE patients, present in nephrotic kidney, enriched for autoreactive specificities and correlates with defined clinical manifestations. IL-21 can potently induce CD11chiT-bet+ B cells and promote the differentiation of these cells into Ig-secreting autoreactive plasma cells. While murine studies have identified a role for T-bet-expressing B cells in autoimmunity, this study describes and exemplifies the importance of CD11chiT-bet+ B cells in human SLE.

Suggested Citation

  • Shu Wang & Jingya Wang & Varsha Kumar & Jodi L. Karnell & Brian Naiman & Phillip S. Gross & Saifur Rahman & Kamelia Zerrouki & Richard Hanna & Christopher Morehouse & Nicholas Holoweckyj & Hao Liu & Z, 2018. "IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03750-7
    DOI: 10.1038/s41467-018-03750-7
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    Cited by:

    1. Russell C. Levack & Krista L. Newell & Berenice Cabrera-Martinez & Justin Cox & Andras Perl & Sheldon I. Bastacky & Gary M. Winslow, 2022. "Adenosine receptor 2a agonists target mouse CD11c+T-bet+ B cells in infection and autoimmunity," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Marta Iborra-Pernichi & Jonathan Ruiz García & María Velasco de la Esperanza & Belén S. Estrada & Elena R. Bovolenta & Claudia Cifuentes & Cristina Prieto Carro & Tamara González Martínez & José Garcí, 2024. "Defective mitochondria remodelling in B cells leads to an aged immune response," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    3. Garrett Dunlap & Aaron Wagner & Nida Meednu & Ruoqiao Wang & Fan Zhang & Jabea Cyril Ekabe & Anna Helena Jonsson & Kevin Wei & Saori Sakaue & Aparna Nathan & Vivian P. Bykerk & Laura T. Donlin & Susan, 2024. "Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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