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A vaccinia-based single vector construct multi-pathogen vaccine protects against both Zika and chikungunya viruses

Author

Listed:
  • Natalie A. Prow

    (QIMR Berghofer Medical Research Institute
    Australian Infectious Disease Research Centre)

  • Liang Liu

    (University of South Australia)

  • Eri Nakayama

    (QIMR Berghofer Medical Research Institute
    National Institute of Infectious Diseases)

  • Tamara H. Cooper

    (University of South Australia)

  • Kexin Yan

    (QIMR Berghofer Medical Research Institute)

  • Preethi Eldi

    (University of South Australia)

  • Jessamine E. Hazlewood

    (QIMR Berghofer Medical Research Institute)

  • Bing Tang

    (QIMR Berghofer Medical Research Institute)

  • Thuy T. Le

    (QIMR Berghofer Medical Research Institute)

  • Yin Xiang Setoh

    (University of Queensland)

  • Alexander A Khromykh

    (Australian Infectious Disease Research Centre
    University of Queensland)

  • Jody Hobson-Peters

    (University of Queensland)

  • Kerrilyn R. Diener

    (University of South Australia
    University of Adelaide)

  • Paul M. Howley

    (Sementis Ltd.)

  • John D. Hayball

    (University of South Australia
    University of Adelaide)

  • Andreas Suhrbier

    (QIMR Berghofer Medical Research Institute
    Australian Infectious Disease Research Centre)

Abstract

Zika and chikungunya viruses have caused major epidemics and are transmitted by Aedes aegypti and/or Aedes albopictus mosquitoes. The “Sementis Copenhagen Vector” (SCV) system is a recently developed vaccinia-based, multiplication-defective, vaccine vector technology that allows manufacture in modified CHO cells. Herein we describe a single-vector construct SCV vaccine that encodes the structural polyprotein cassettes of both Zika and chikungunya viruses from different loci. A single vaccination of mice induces neutralizing antibodies to both viruses in wild-type and IFNAR−/− mice and protects against (i) chikungunya virus viremia and arthritis in wild-type mice, (ii) Zika virus viremia and fetal/placental infection in female IFNAR−/− mice, and (iii) Zika virus viremia and testes infection and pathology in male IFNAR−/− mice. To our knowledge this represents the first single-vector construct, multi-pathogen vaccine encoding large polyproteins, and offers both simplified manufacturing and formulation, and reduced “shot burden” for these often co-circulating arboviruses.

Suggested Citation

  • Natalie A. Prow & Liang Liu & Eri Nakayama & Tamara H. Cooper & Kexin Yan & Preethi Eldi & Jessamine E. Hazlewood & Bing Tang & Thuy T. Le & Yin Xiang Setoh & Alexander A Khromykh & Jody Hobson-Peters, 2018. "A vaccinia-based single vector construct multi-pathogen vaccine protects against both Zika and chikungunya viruses," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03662-6
    DOI: 10.1038/s41467-018-03662-6
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    Cited by:

    1. Taha Azad & Reza Rezaei & Ragunath Singaravelu & Adrian Pelin & Stephen Boulton & Julia Petryk & Kemal Alper Onsu & Nikolas T. Martin & Victoria Hoskin & Mina Ghahremani & Marie Marotel & Ricardo Mari, 2023. "Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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