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Time-dependent memory transformation along the hippocampal anterior–posterior axis

Author

Listed:
  • Lisa C. Dandolo

    (University of Hamburg)

  • Lars Schwabe

    (University of Hamburg)

Abstract

With time, memories undergo a neural reorganization that is linked to a transformation of detailed, episodic into more semantic, gist-like memory. Traditionally, this reorganization is thought to involve a redistribution of memory from the hippocampus to neocortical areas. Here we report a time-dependent reorganization within the hippocampus, along its anterior–posterior axis, that is related to the transformation of detailed memories into gist-like representations. We show that mnemonic representations in the anterior hippocampus are highly distinct and that anterior hippocampal activity is associated with detailed memory but decreases over time. Posterior hippocampal representations, however, are more gist-like at a later retention interval, and do not decline over time. These findings indicate that, in addition to the well-known systems consolidation from hippocampus to neocortex, there are changes within the hippocampus that are crucial for the temporal dynamics of memory.

Suggested Citation

  • Lisa C. Dandolo & Lars Schwabe, 2018. "Time-dependent memory transformation along the hippocampal anterior–posterior axis," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03661-7
    DOI: 10.1038/s41467-018-03661-7
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    Cited by:

    1. Valentina Krenz & Tobias Sommer & Arjen Alink & Benno Roozendaal & Lars Schwabe, 2021. "Noradrenergic arousal after encoding reverses the course of systems consolidation in humans," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    2. Valentina Krenz & Arjen Alink & Tobias Sommer & Benno Roozendaal & Lars Schwabe, 2023. "Time-dependent memory transformation in hippocampus and neocortex is semantic in nature," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Joseph I. Terranova & Jun Yokose & Hisayuki Osanai & Sachie K. Ogawa & Takashi Kitamura, 2023. "Systems consolidation induces multiple memory engrams for a flexible recall strategy in observational fear memory in male mice," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Sam Audrain & Mary Pat McAndrews, 2022. "Schemas provide a scaffold for neocortical integration of new memories over time," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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