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Designed heterogeneous palladium catalysts for reversible light-controlled bioorthogonal catalysis in living cells

Author

Listed:
  • Faming Wang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yan Zhang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Zhi Du

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Jinsong Ren

    (Chinese Academy of Sciences)

  • Xiaogang Qu

    (Chinese Academy of Sciences)

Abstract

As a powerful tool for chemical biology, bioorthogonal chemistry broadens the ways to explore the mystery of life. In this field, transition metal catalysts (TMCs) have received much attention because TMCs can rapidly catalyze chemical transformations that cannot be accomplished by bio-enzymes. However, fine controlling chemical reactions in living systems like bio-enzymes is still a great challenge. Herein, we construct a versatile light-controlled bioorthogonal catalyst by modifying macroporous silica-Pd0 with supramolecular complex of azobenzene (Azo) and β-cyclodextrin (CD). Its catalytic activity can be regulated by light-induced structural changes, mimicking allosteric regulation mechanism of bio-enzymes. The light-gated heterogeneous TMCs are important for in situ controlling bioorthogonal reactions and have been successfully used to synthesize a fluorescent probe for cell imaging and mitochondria-specific targeting agent by Suzuki–Miyaura cross-coupling reaction. Endowing the bioorthogonal catalyst with new functions is highly valuable for realizing more complex researches in biochemistry.

Suggested Citation

  • Faming Wang & Yan Zhang & Zhi Du & Jinsong Ren & Xiaogang Qu, 2018. "Designed heterogeneous palladium catalysts for reversible light-controlled bioorthogonal catalysis in living cells," Nature Communications, Nature, vol. 9(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03617-x
    DOI: 10.1038/s41467-018-03617-x
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    Cited by:

    1. Qing Hong & Hong Yang & Yanfeng Fang & Wang Li & Caixia Zhu & Zhuang Wang & Sicheng Liang & Xuwen Cao & Zhixin Zhou & Yanfei Shen & Songqin Liu & Yuanjian Zhang, 2023. "Adaptable graphitic C6N6-based copper single-atom catalyst for intelligent biosensing," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Zhaokui Jin & Lingdong Jiang & Qianjun He, 2024. "Critical learning from industrial catalysis for nanocatalytic medicine," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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