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A biochemical network controlling basal myosin oscillation

Author

Listed:
  • Xiang Qin

    (Université de Toulouse, UPS
    CNRS, LBCMCP
    University of Electronic Science and Technology of China)

  • Edouard Hannezo

    (University of Cambridge
    Institute of Science and Technology Austria)

  • Thomas Mangeat

    (Université de Toulouse, UPS
    CNRS, LBCMCP)

  • Chang Liu

    (Université de Toulouse, UPS
    CNRS, LBCMCP
    Third Military Medical University)

  • Pralay Majumder

    (Presidency University)

  • Jiaying Liu

    (Université de Toulouse, UPS
    CNRS, LBCMCP)

  • Valerie Choesmel-Cadamuro

    (Université de Toulouse, UPS
    CNRS, LBCMCP)

  • Jocelyn A. McDonald

    (Kansas State University)

  • Yiyao Liu

    (University of Electronic Science and Technology of China)

  • Bin Yi

    (Third Military Medical University)

  • Xiaobo Wang

    (Université de Toulouse, UPS
    CNRS, LBCMCP)

Abstract

The actomyosin cytoskeleton, a key stress-producing unit in epithelial cells, oscillates spontaneously in a wide variety of systems. Although much of the signal cascade regulating myosin activity has been characterized, the origin of such oscillatory behavior is still unclear. Here, we show that basal myosin II oscillation in Drosophila ovarian epithelium is not controlled by actomyosin cortical tension, but instead relies on a biochemical oscillator involving ROCK and myosin phosphatase. Key to this oscillation is a diffusive ROCK flow, linking junctional Rho1 to medial actomyosin cortex, and dynamically maintained by a self-activation loop reliant on ROCK kinase activity. In response to the resulting myosin II recruitment, myosin phosphatase is locally enriched and shuts off ROCK and myosin II signals. Coupling Drosophila genetics, live imaging, modeling, and optogenetics, we uncover an intrinsic biochemical oscillator at the core of myosin II regulatory network, shedding light on the spatio-temporal dynamics of force generation.

Suggested Citation

  • Xiang Qin & Edouard Hannezo & Thomas Mangeat & Chang Liu & Pralay Majumder & Jiaying Liu & Valerie Choesmel-Cadamuro & Jocelyn A. McDonald & Yiyao Liu & Bin Yi & Xiaobo Wang, 2018. "A biochemical network controlling basal myosin oscillation," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03574-5
    DOI: 10.1038/s41467-018-03574-5
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    Cited by:

    1. Shun Li & Zong-Yuan Liu & Hao Li & Sijia Zhou & Jiaying Liu & Ningwei Sun & Kai-Fu Yang & Vanessa Dougados & Thomas Mangeat & Karine Belguise & Xi-Qiao Feng & Yiyao Liu & Xiaobo Wang, 2024. "Basal actomyosin pulses expand epithelium coordinating cell flattening and tissue elongation," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    2. Alexis Villars & Alexis Matamoro-Vidal & Florence Levillayer & Romain Levayer, 2022. "Microtubule disassembly by caspases is an important rate-limiting step of cell extrusion," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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