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nc886 is induced by TGF-β and suppresses the microRNA pathway in ovarian cancer

Author

Listed:
  • Ji-Hye Ahn

    (Kyung Hee University)

  • Hyun-Sung Lee

    (Baylor College of Medicine)

  • Ju-Seog Lee

    (University of Texas MD Anderson Cancer Center)

  • Yeon-Su Lee

    (National Cancer Center)

  • Jong-Lyul Park

    (KRIBB)

  • Seon-Young Kim

    (KRIBB)

  • Jung-Ah Hwang

    (National Cancer Center)

  • Nawapol Kunkeaw

    (University of Texas Medical Branch
    Mahidol University)

  • Sung Yun Jung

    (Baylor College of Medicine)

  • Tae Jin Kim

    (College of Medicine Dankook University)

  • Kwang-Soo Lee

    (Hallym University)

  • Sung Ho Jeon

    (Hallym University)

  • Inhan Lee

    (miRcore)

  • Betty H. Johnson

    (University of Texas Medical Branch)

  • Jung-Hye Choi

    (Kyung Hee University)

  • Yong Sun Lee

    (University of Texas Medical Branch
    National Cancer Center)

Abstract

Transforming growth factor-β (TGF-β) signaling and microRNAs (miRNAs) are important gene regulatory components in cancer. Usually in advanced malignant stages, TGF-β signaling is elevated but global miRNA expression is suppressed. Such a gene expression signature is well illustrated in a fibrosis (or mesenchymal) subtype of ovarian cancer (OC) that is of poor prognosis. However, the interplay between the two pathways in the OC subtype has not yet been elucidated. nc886 is a recently identified non-coding RNA implicated in several malignancies. The high expression of nc886 is associated with poor prognosis in 285 OC patients. Herein, we find that in OC nc886 expression is induced by TGF-β and that nc886 binds to Dicer to inhibit miRNA maturation. By preventing the miRNA pathway, nc886 emulates TGF-β in gene expression patterns and potentiates cell adhesion, migration, invasion, and drug resistance. Here we report nc886 to be a molecular link between the TGF-β and miRNA pathways.

Suggested Citation

  • Ji-Hye Ahn & Hyun-Sung Lee & Ju-Seog Lee & Yeon-Su Lee & Jong-Lyul Park & Seon-Young Kim & Jung-Ah Hwang & Nawapol Kunkeaw & Sung Yun Jung & Tae Jin Kim & Kwang-Soo Lee & Sung Ho Jeon & Inhan Lee & Be, 2018. "nc886 is induced by TGF-β and suppresses the microRNA pathway in ovarian cancer," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03556-7
    DOI: 10.1038/s41467-018-03556-7
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