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A bright organic NIR-II nanofluorophore for three-dimensional imaging into biological tissues

Author

Listed:
  • Hao Wan

    (South University of Science and Technology of China
    Stanford University)

  • Jingying Yue

    (Stanford University)

  • Shoujun Zhu

    (Stanford University)

  • Takaaki Uno

    (Stanford University
    Advanced Materials Research Laboratories)

  • Xiaodong Zhang

    (Tianjin University)

  • Qinglai Yang

    (South University of Science and Technology of China
    Tsinghua University)

  • Kuai Yu

    (Stanford University)

  • Guosong Hong

    (Stanford University)

  • Junying Wang

    (Tianjin University)

  • Lulin Li

    (VA Palo Alto Health Care System)

  • Zhuoran Ma

    (Stanford University)

  • Hongpeng Gao

    (Stanford University)

  • Yeteng Zhong

    (Stanford University)

  • Jessica Su

    (Stanford University)

  • Alexander L. Antaris

    (Stanford University)

  • Yan Xia

    (Stanford University)

  • Jian Luo

    (VA Palo Alto Health Care System
    Stanford University)

  • Yongye Liang

    (South University of Science and Technology of China)

  • Hongjie Dai

    (Stanford University)

Abstract

Fluorescence imaging of biological systems in the second near-infrared (NIR-II, 1000–1700 nm) window has shown promise of high spatial resolution, low background, and deep tissue penetration owing to low autofluorescence and suppressed scattering of long wavelength photons. Here we develop a bright organic nanofluorophore (named p-FE) for high-performance biological imaging in the NIR-II window. The bright NIR-II >1100 nm fluorescence emission from p-FE affords non-invasive in vivo tracking of blood flow in mouse brain vessels. Excitingly, p-FE enables one-photon based, three-dimensional (3D) confocal imaging of vasculatures in fixed mouse brain tissue with a layer-by-layer imaging depth up to ~1.3 mm and sub-10 µm high spatial resolution. We also perform in vivo two-color fluorescence imaging in the NIR-II window by utilizing p-FE as a vasculature imaging agent emitting between 1100 and 1300 nm and single-walled carbon nanotubes (CNTs) emitting above 1500 nm to highlight tumors in mice.

Suggested Citation

  • Hao Wan & Jingying Yue & Shoujun Zhu & Takaaki Uno & Xiaodong Zhang & Qinglai Yang & Kuai Yu & Guosong Hong & Junying Wang & Lulin Li & Zhuoran Ma & Hongpeng Gao & Yeteng Zhong & Jessica Su & Alexande, 2018. "A bright organic NIR-II nanofluorophore for three-dimensional imaging into biological tissues," Nature Communications, Nature, vol. 9(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03505-4
    DOI: 10.1038/s41467-018-03505-4
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    Cited by:

    1. Chao Mi & Xun Zhang & Chengyu Yang & Jianqun Wu & Xinxin Chen & Chenguang Ma & Sitong Wu & Zhichao Yang & Pengzhen Qiao & Yang Liu & Weijie Wu & Zhiyong Guo & Jiayan Liao & Jiajia Zhou & Ming Guan & C, 2023. "Bone disease imaging through the near-infrared-II window," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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