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Hydrogen peroxide positively regulates brassinosteroid signaling through oxidation of the BRASSINAZOLE-RESISTANT1 transcription factor

Author

Listed:
  • Yanchen Tian

    (Shandong University)

  • Min Fan

    (Shandong University)

  • Zhaoxia Qin

    (Shandong University)

  • Hongjun Lv

    (Shandong University)

  • Minmin Wang

    (Shandong University)

  • Zhe Zhang

    (Fujian Agriculture and Forestry University)

  • Wenying Zhou

    (Shandong University)

  • Na Zhao

    (Shandong University)

  • Xiaohui Li

    (Shandong University)

  • Chao Han

    (Shandong University)

  • Zhaojun Ding

    (Shandong University)

  • Wenfei Wang

    (Fujian Agriculture and Forestry University)

  • Zhi-Yong Wang

    (Carnegie Institution for Science)

  • Ming-Yi Bai

    (Shandong University)

Abstract

Hydrogen peroxide (H2O2) is an important signaling molecule in plant developmental processes and stress responses. However, whether H2O2-mediated signaling crosstalks with plant hormone signaling is largely unclear. Here, we show that H2O2 induces the oxidation of the BRASSINAZOLE-RESISTANT1 (BZR1) transcription factor, which functions as a master regulator of brassinosteroid (BR) signaling. Oxidative modification enhances BZR1 transcriptional activity by promoting its interaction with key regulators in the auxin-signaling and light-signaling pathways, including AUXIN RESPONSE FACTOR6 (ARF6) and PHYTOCHROME INTERACTING FACTOR4 (PIF4). Genome-wide analysis shows that H2O2-dependent regulation of BZR1 activity plays a major role in modifying gene expression related to several BR-mediated biological processes. Furthermore, we show that the thioredoxin TRXh5 can interact with BZR1 and catalyzes its reduction. We conclude that reversible oxidation of BZR1 connects H2O2-mediated and thioredoxin-mediated redox signaling to BR signaling to regulate plant development.

Suggested Citation

  • Yanchen Tian & Min Fan & Zhaoxia Qin & Hongjun Lv & Minmin Wang & Zhe Zhang & Wenying Zhou & Na Zhao & Xiaohui Li & Chao Han & Zhaojun Ding & Wenfei Wang & Zhi-Yong Wang & Ming-Yi Bai, 2018. "Hydrogen peroxide positively regulates brassinosteroid signaling through oxidation of the BRASSINAZOLE-RESISTANT1 transcription factor," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03463-x
    DOI: 10.1038/s41467-018-03463-x
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    Cited by:

    1. Wen Shi & Yue Liu & Na Zhao & Lianmei Yao & Jinge Li & Min Fan & Bojian Zhong & Ming-Yi Bai & Chao Han, 2024. "Hydrogen peroxide is required for light-induced stomatal opening across different plant species," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Wen Shi & Lingyan Wang & Lianmei Yao & Wei Hao & Chao Han & Min Fan & Wenfei Wang & Ming-Yi Bai, 2022. "Spatially patterned hydrogen peroxide orchestrates stomatal development in Arabidopsis," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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