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Role of monkeys in the sylvatic cycle of chikungunya virus in Senegal

Author

Listed:
  • Benjamin M. Althouse

    (Institute for Disease Modeling
    University of Washington
    New Mexico State University)

  • Mathilde Guerbois

    (University of Texas Medical Branch)

  • Derek A. T. Cummings

    (University of Florida)

  • Ousmane M. Diop

    (Institut Pasteur de Dakar)

  • Ousmane Faye

    (Institut Pasteur de Dakar)

  • Abdourahmane Faye

    (Institut Pasteur de Dakar)

  • Diawo Diallo

    (Institut Pasteur de Dakar)

  • Bakary Djilocalisse Sadio

    (Institut Pasteur de Dakar)

  • Abdourahmane Sow

    (Institut Pasteur de Dakar)

  • Oumar Faye

    (Institut Pasteur de Dakar)

  • Amadou A. Sall

    (Institut Pasteur de Dakar)

  • Mawlouth Diallo

    (Institut Pasteur de Dakar)

  • Brenda Benefit

    (New Mexico State University)

  • Evan Simons

    (New Mexico State University)

  • Douglas M. Watts

    (University of Texas at El Paso
    University of Texas Medical Branch)

  • Scott C. Weaver

    (University of Texas Medical Branch)

  • Kathryn A. Hanley

    (New Mexico State University)

Abstract

Arboviruses spillover into humans either as a one-step jump from a reservoir host species into humans or as a two-step jump from the reservoir to an amplification host species and thence to humans. Little is known about arbovirus transmission dynamics in reservoir and amplification hosts. Here we elucidate the role of monkeys in the sylvatic, enzootic cycle of chikungunya virus (CHIKV) in the region around Kédougou, Senegal. Over 3 years, 737 monkeys were captured, aged using anthropometry and dentition, and tested for exposure to CHIKV by detection of neutralizing antibodies. Infant monkeys were positive for CHIKV even when the virus was not detected in a concurrent survey of mosquitoes and when population immunity was too high for monkeys alone to support continuous transmission. We conclude that monkeys in this region serve as amplification hosts of CHIKV. Additional efforts are needed to identify other hosts capable of supporting continuous circulation.

Suggested Citation

  • Benjamin M. Althouse & Mathilde Guerbois & Derek A. T. Cummings & Ousmane M. Diop & Ousmane Faye & Abdourahmane Faye & Diawo Diallo & Bakary Djilocalisse Sadio & Abdourahmane Sow & Oumar Faye & Amadou, 2018. "Role of monkeys in the sylvatic cycle of chikungunya virus in Senegal," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03332-7
    DOI: 10.1038/s41467-018-03332-7
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    Cited by:

    1. Kathryn A. Hanley & Hélène Cecilia & Sasha R. Azar & Brett A. Moehn & Jordan T. Gass & Natalia I. Oliveira da Silva & Wanqin Yu & Ruimei Yun & Benjamin M. Althouse & Nikos Vasilakis & Shannan L. Rossi, 2024. "Trade-offs shaping transmission of sylvatic dengue and Zika viruses in monkey hosts," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Dan Wen & Limin S. Ding & Yanan Zhang & Xiaoye Li & Xing Zhang & Fei Yuan & Tongbiao Zhao & Aihua Zheng, 2022. "Suppression of flavivirus transmission from animal hosts to mosquitoes with a mosquito-delivered vaccine," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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