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Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum

Author

Listed:
  • Marlena S. Fejzo

    (University of California at Los Angeles
    University of Southern California)

  • Olga V. Sazonova

    (23andMe, Inc.)

  • J. Fah Sathirapongsasuti

    (23andMe, Inc.)

  • Ingileif B. Hallgrímsdóttir

    (23andMe, Inc.
    Amgen Inc.)

  • Vladimir Vacic

    (23andMe, Inc.)

  • Kimber W. MacGibbon

    (Hyperemesis Education and Research Foundation)

  • Frederic P. Schoenberg

    (University of California, Los Angeles)

  • Nicholas Mancuso

    (University of California at Los Angeles)

  • Dennis J. Slamon

    (University of California at Los Angeles)

  • Patrick M. Mullin

    (University of Southern California)

Abstract

Hyperemesis gravidarum (HG), severe nausea and vomiting of pregnancy, occurs in 0.3–2% of pregnancies and is associated with maternal and fetal morbidity. The cause of HG remains unknown, but familial aggregation and results of twin studies suggest that understanding the genetic contribution is essential for comprehending the disease etiology. Here, we conduct a genome-wide association study (GWAS) for binary (HG) and ordinal (severity of nausea and vomiting) phenotypes of pregnancy complications. Two loci, chr19p13.11 and chr4q12, are genome-wide significant (p

Suggested Citation

  • Marlena S. Fejzo & Olga V. Sazonova & J. Fah Sathirapongsasuti & Ingileif B. Hallgrímsdóttir & Vladimir Vacic & Kimber W. MacGibbon & Frederic P. Schoenberg & Nicholas Mancuso & Dennis J. Slamon & Pat, 2018. "Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum," Nature Communications, Nature, vol. 9(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03258-0
    DOI: 10.1038/s41467-018-03258-0
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    Cited by:

    1. Maik Pietzner & Eleanor Wheeler & Julia Carrasco-Zanini & Nicola D. Kerrison & Erin Oerton & Mine Koprulu & Jian’an Luan & Aroon D. Hingorani & Steve A. Williams & Nicholas J. Wareham & Claudia Langen, 2021. "Synergistic insights into human health from aptamer- and antibody-based proteomic profiling," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

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