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Tailed giant Tupanvirus possesses the most complete translational apparatus of the known virosphere

Author

Listed:
  • Jônatas Abrahão

    (IHU-Méditerranee Infection
    Universidade Federal de Minas Gerais)

  • Lorena Silva

    (IHU-Méditerranee Infection
    Universidade Federal de Minas Gerais)

  • Ludmila Santos Silva

    (IHU-Méditerranee Infection
    Universidade Federal de Minas Gerais)

  • Jacques Yaacoub Bou Khalil

    (CNRS)

  • Rodrigo Rodrigues

    (Universidade Federal de Minas Gerais)

  • Thalita Arantes

    (Universidade Federal de Minas Gerais)

  • Felipe Assis

    (Universidade Federal de Minas Gerais)

  • Paulo Boratto

    (Universidade Federal de Minas Gerais)

  • Miguel Andrade

    (Universidade de Brasília, Asa Norte)

  • Erna Geessien Kroon

    (Universidade Federal de Minas Gerais)

  • Bergmann Ribeiro

    (Universidade de Brasília, Asa Norte)

  • Ivan Bergier

    (Embrapa Pantanal)

  • Herve Seligmann

    (IHU-Méditerranee Infection)

  • Eric Ghigo

    (IHU-Méditerranee Infection)

  • Philippe Colson

    (IHU-Méditerranee Infection)

  • Anthony Levasseur

    (IHU-Méditerranee Infection)

  • Guido Kroemer

    (Gustave Roussy Cancer Campus
    Centre de Recherche des Cordeliers
    Institut National de la Santé et de la Recherche Médicale (INSERM)
    Sorbonne Paris Cité)

  • Didier Raoult

    (IHU-Méditerranee Infection)

  • Bernard La Scola

    (IHU-Méditerranee Infection)

Abstract

Here we report the discovery of two Tupanvirus strains, the longest tailed Mimiviridae members isolated in amoebae. Their genomes are 1.44–1.51 Mb linear double-strand DNA coding for 1276–1425 predicted proteins. Tupanviruses share the same ancestors with mimivirus lineages and these giant viruses present the largest translational apparatus within the known virosphere, with up to 70 tRNA, 20 aaRS, 11 factors for all translation steps, and factors related to tRNA/mRNA maturation and ribosome protein modification. Moreover, two sequences with significant similarity to intronic regions of 18 S rRNA genes are encoded by the tupanviruses and highly expressed. In this translation-associated gene set, only the ribosome is lacking. At high multiplicity of infections, tupanvirus is also cytotoxic and causes a severe shutdown of ribosomal RNA and a progressive degradation of the nucleus in host and non-host cells. The analysis of tupanviruses constitutes a new step toward understanding the evolution of giant viruses.

Suggested Citation

  • Jônatas Abrahão & Lorena Silva & Ludmila Santos Silva & Jacques Yaacoub Bou Khalil & Rodrigo Rodrigues & Thalita Arantes & Felipe Assis & Paulo Boratto & Miguel Andrade & Erna Geessien Kroon & Bergman, 2018. "Tailed giant Tupanvirus possesses the most complete translational apparatus of the known virosphere," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03168-1
    DOI: 10.1038/s41467-018-03168-1
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