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Functional architecture of reward learning in mushroom body extrinsic neurons of larval Drosophila

Author

Listed:
  • Timo Saumweber

    (Leibniz Institute for Neurobiology (LIN))

  • Astrid Rohwedder

    (University of Konstanz)

  • Michael Schleyer

    (Leibniz Institute for Neurobiology (LIN))

  • Katharina Eichler

    (University of Konstanz
    HHMI Janelia Research Campus)

  • Yi-chun Chen

    (Leibniz Institute for Neurobiology (LIN))

  • Yoshinori Aso

    (HHMI Janelia Research Campus)

  • Albert Cardona

    (HHMI Janelia Research Campus)

  • Claire Eschbach

    (HHMI Janelia Research Campus)

  • Oliver Kobler

    (Leibniz Institute for Neurobiology (LIN))

  • Anne Voigt

    (Leibniz Institute for Neurobiology (LIN))

  • Archana Durairaja

    (Leibniz Institute for Neurobiology (LIN))

  • Nino Mancini

    (Leibniz Institute for Neurobiology (LIN))

  • Marta Zlatic

    (HHMI Janelia Research Campus)

  • James W. Truman

    (HHMI Janelia Research Campus
    University of Washington)

  • Andreas S. Thum

    (University of Konstanz
    University of Konstanz
    University of Leipzig)

  • Bertram Gerber

    (Leibniz Institute for Neurobiology (LIN)
    Center for Behavioral Brain Sciences (CBBS)
    Otto von Guericke University Magdeburg)

Abstract

The brain adaptively integrates present sensory input, past experience, and options for future action. The insect mushroom body exemplifies how a central brain structure brings about such integration. Here we use a combination of systematic single-cell labeling, connectomics, transgenic silencing, and activation experiments to study the mushroom body at single-cell resolution, focusing on the behavioral architecture of its input and output neurons (MBINs and MBONs), and of the mushroom body intrinsic APL neuron. Our results reveal the identity and morphology of almost all of these 44 neurons in stage 3 Drosophila larvae. Upon an initial screen, functional analyses focusing on the mushroom body medial lobe uncover sparse and specific functions of its dopaminergic MBINs, its MBONs, and of the GABAergic APL neuron across three behavioral tasks, namely odor preference, taste preference, and associative learning between odor and taste. Our results thus provide a cellular-resolution study case of how brains organize behavior.

Suggested Citation

  • Timo Saumweber & Astrid Rohwedder & Michael Schleyer & Katharina Eichler & Yi-chun Chen & Yoshinori Aso & Albert Cardona & Claire Eschbach & Oliver Kobler & Anne Voigt & Archana Durairaja & Nino Manci, 2018. "Functional architecture of reward learning in mushroom body extrinsic neurons of larval Drosophila," Nature Communications, Nature, vol. 9(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03130-1
    DOI: 10.1038/s41467-018-03130-1
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    Cited by:

    1. Fangmin Zhou & Alexandra-Madelaine Tichy & Bibi Nusreen Imambocus & Shreyas Sakharwade & Francisco J. Rodriguez Jimenez & Marco González Martínez & Ishrat Jahan & Margarita Habib & Nina Wilhelmy & Van, 2023. "Optimized design and in vivo application of optogenetically functionalized Drosophila dopamine receptors," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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