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Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4

Author

Listed:
  • Ning Lu

    (Chinese Academy of Sciences
    The University of Texas M.D. Anderson Cancer Center)

  • Ying Li

    (Chinese Academy of Sciences)

  • Zhiqiang Zhang

    (The University of Texas M.D. Anderson Cancer Center
    Texas Medical Center)

  • Junji Xing

    (Texas Medical Center)

  • Ying Sun

    (King’s College London
    Capital Medical University)

  • Sheng Yao

    (Yale University School of Medicine
    TopAlliance Biosciences)

  • Lieping Chen

    (Yale University School of Medicine)

Abstract

Semaphorin-4A (Sema4A) has been implicated in the co-stimulation of T cells and drives Th1 immune responses by binding to the receptor T-cell immunoglobulin and mucin domain protein 2 (Tim-2) in mice. Here we show that human, but not murine, Sema4A is preferentially expressed on antigen-presenting cells, and co-stimulates CD4+ T-cell proliferation and drives Th2 responses. By employing two independent cloning strategies, we demonstrate that Immunoglobulin-like transcript 4 (ILT-4) is a receptor for human SEMA4A (hSEMA4A) on activated CD4+ T cells. We also find hSEMA4A to be highly expressed in human asthmatic lung tissue, implying its potential function in disease pathogenesis. Our study defines a different biological function of hSEMA4A from its murine homolog through its binding to the receptor of ILT-4 to co-stimulate CD4+T cells and regulate Th2 cells differentiation.

Suggested Citation

  • Ning Lu & Ying Li & Zhiqiang Zhang & Junji Xing & Ying Sun & Sheng Yao & Lieping Chen, 2018. "Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03128-9
    DOI: 10.1038/s41467-018-03128-9
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