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USP35 regulates mitotic progression by modulating the stability of Aurora B

Author

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  • Jinyoung Park

    (Korea Institute of Science and Technology)

  • Mi-Sun Kwon

    (Seoul National University)

  • Eunice EunKyeong Kim

    (Korea Institute of Science and Technology)

  • Hyunsook Lee

    (Seoul National University)

  • Eun Joo Song

    (Korea Institute of Science and Technology
    Korea University of Science and Technology)

Abstract

Although approximately 100 deubiquitinating enzymes (DUBs) are encoded in the human genome, very little is known about the DUBs that function in mitosis. Here, we demonstrate that DUB USP35 functions as a mitotic regulator by controlling the protein levels and downstream signaling of Aurora B and the depletion of USP35 eventually leads to several mitotic defects including cytokinesis failures. USP35 binds to and deubiquitinates Aurora B, and inhibits the APCCDH1-mediated proteasomal degradation of Aurora B, thus maintaining its steady-state levels during mitosis. In addition, the loss of USP35 decreases the phosphorylation of histone H3-Ser10, an Aurora B substrate. Finally, the transcription factor FoxM1 promotes the expression of USP35, as well as that of Aurora B, during the cell cycle. Our findings suggest that USP35 regulates the stability and function of Aurora B by blocking APCCDH1-induced proteasomal degradation, thereby controlling mitotic progression.

Suggested Citation

  • Jinyoung Park & Mi-Sun Kwon & Eunice EunKyeong Kim & Hyunsook Lee & Eun Joo Song, 2018. "USP35 regulates mitotic progression by modulating the stability of Aurora B," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03107-0
    DOI: 10.1038/s41467-018-03107-0
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    Cited by:

    1. Yu-Hsuan Chen & Han-Hsiun Chen & Won-Jing Wang & Hsin-Yi Chen & Wei-Syun Huang & Chien-Han Kao & Sin-Rong Lee & Nai Yang Yeat & Ruei-Liang Yan & Shu-Jou Chan & Kuen-Phon Wu & Ruey-Hwa Chen, 2023. "TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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