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Tridimensional visualization reveals direct communication between the embryo and glands critical for implantation

Author

Listed:
  • Jia Yuan

    (Cincinnati Children’s Hospital Medical Center)

  • Wenbo Deng

    (Cincinnati Children’s Hospital Medical Center)

  • Jeeyeon Cha

    (Vanderbilt University Medical Center)

  • Xiaofei Sun

    (Cincinnati Children’s Hospital Medical Center)

  • Jean-Paul Borg

    (Inst Paoli-Calmettes, UMR7258 CNRS, U1068 INSERM, Cell Polarity, Cell signalling and Cancer - Equipe labellisée Ligue Contre le Cancer)

  • Sudhansu. K. Dey

    (Cincinnati Children’s Hospital Medical Center)

Abstract

Embryo implantation is central to pregnancy success. Our previous understanding is limited by studying this phenomenon primarily in two dimensions. Here we employ 3D visualization, revealing that epithelial evaginations that form implantation chambers (crypts) consistently arise with preexisting glands, suggesting direct access of glands to embryos within the chamber. While the lobular domains of the glands become more developed, the ductal regions continue to elongate and progressively stretch following implantation. Using diapausing mice and mice with deletion of the planar cell polarity gene Vangl2 in uterine epithelial cells, we show that dynamic changes in gland topography depend on implantation-competent blastocysts and planar cell polarity. By transferring blastocyst-size beads preloaded with HB-EGF in pseudopregnant mice, we found that HB-EGF is a trigger for the communication between embryos and glands. Glands directly connecting the crypt encasing the embryo during implantation are therefore fundamental to pregnancy success.

Suggested Citation

  • Jia Yuan & Wenbo Deng & Jeeyeon Cha & Xiaofei Sun & Jean-Paul Borg & Sudhansu. K. Dey, 2018. "Tridimensional visualization reveals direct communication between the embryo and glands critical for implantation," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03092-4
    DOI: 10.1038/s41467-018-03092-4
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    Cited by:

    1. Meng Liu & Mengjun Ji & Jianghong Cheng & Yingzhe Li & Yingpu Tian & Hui Zhao & Yang Wang & Sijing Zhu & Leilei Zhang & Xinmei Xu & Gen-Sheng Feng & Xiaohuan Liang & Haili Bao & Yedong Tang & Shuangbo, 2023. "Deciphering a critical role of uterine epithelial SHP2 in parturition initiation at single cell resolution," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Sangappa B. Chadchan & Pooja Popli & Zian Liao & Eryk Andreas & Michelle Dias & Tianyuan Wang & Stephanie J. Gunderson & Patricia T. Jimenez & Denise G. Lanza & Rainer B. Lanz & Charles E. Foulds & Di, 2024. "A GREB1-steroid receptor feedforward mechanism governs differential GREB1 action in endometrial function and endometriosis," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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