IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-03073-7.html
   My bibliography  Save this article

Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging

Author

Listed:
  • Gabriel Oh

    (Centre for Addiction and Mental Health)

  • Sasha Ebrahimi

    (Centre for Addiction and Mental Health)

  • Matthew Carlucci

    (Centre for Addiction and Mental Health)

  • Aiping Zhang

    (Centre for Addiction and Mental Health)

  • Akhil Nair

    (Centre for Addiction and Mental Health)

  • Daniel E. Groot

    (Centre for Addiction and Mental Health)

  • Viviane Labrie

    (Centre for Addiction and Mental Health
    Van Andel Research Institute)

  • Peixin Jia

    (Centre for Addiction and Mental Health)

  • Edward S. Oh

    (Centre for Addiction and Mental Health)

  • Richie H. Jeremian

    (Centre for Addiction and Mental Health)

  • Miki Susic

    (Centre for Addiction and Mental Health)

  • Tenjin C. Shrestha

    (University of Toronto
    University of Toronto)

  • Martin R. Ralph

    (University of Toronto)

  • Juozas Gordevičius

    (Vilnius University
    Vilnius University)

  • Karolis Koncevičius

    (Vilnius University
    Vilnius University)

  • Art Petronis

    (Centre for Addiction and Mental Health
    Vilnius University)

Abstract

Circadian rhythmicity governs a remarkable array of fundamental biological functions and is mediated by cyclical transcriptomic and proteomic activities. Epigenetic factors are also involved in this circadian machinery; however, despite extensive efforts, detection and characterization of circadian cytosine modifications at the nucleotide level have remained elusive. In this study, we report that a large proportion of epigenetically variable cytosines show a circadian pattern in their modification status in mice. Importantly, the cytosines with circadian epigenetic oscillations significantly overlap with the cytosines exhibiting age-related changes in their modification status. Our findings suggest that evolutionary advantageous processes such as circadian rhythmicity can also contribute to an organism’s deterioration.

Suggested Citation

  • Gabriel Oh & Sasha Ebrahimi & Matthew Carlucci & Aiping Zhang & Akhil Nair & Daniel E. Groot & Viviane Labrie & Peixin Jia & Edward S. Oh & Richie H. Jeremian & Miki Susic & Tenjin C. Shrestha & Marti, 2018. "Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03073-7
    DOI: 10.1038/s41467-018-03073-7
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-03073-7
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-03073-7?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Dalia Halawani & Yiqun Wang & Aarthi Ramakrishnan & Molly Estill & Xijing He & Li Shen & Roland H. Friedel & Hongyan Zou, 2023. "Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons," Nature Communications, Nature, vol. 14(1), pages 1-22, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03073-7. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.