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The plant-specific histone residue Phe41 is important for genome-wide H3.1 distribution

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Listed:
  • Li Lu

    (University of Wisconsin-Madison
    University of Wisconsin-Madison)

  • Xiangsong Chen

    (University of Wisconsin-Madison
    University of Wisconsin-Madison)

  • Shuiming Qian

    (University of Wisconsin-Madison
    University of Wisconsin-Madison)

  • Xuehua Zhong

    (University of Wisconsin-Madison
    University of Wisconsin-Madison)

Abstract

The dynamic incorporation of histone variants influences chromatin structure and many biological processes. In Arabidopsis, the canonical variant H3.1 differs from H3.3 in four residues, one of which (H3.1Phe41) is unique and conserved in plants. However, its evolutionary significance remains unclear. Here, we show that Phe41 first appeared in H3.1 in ferns and became stable during land plant evolution. Unlike H3.1, which is specifically enriched in silent regions, H3.1F41Y variants gain ectopic accumulation at actively transcribed regions. Reciprocal tail and core domain swap experiments between H3.1 and H3.3 show that the H3.1 core, while necessary, is insufficient to restrict H3.1 to silent regions. We conclude that the vascular-plant-specific Phe41 is critical for H3.1 genomic distribution and may act collaboratively with the H3.1 core to regulate deposition patterns. This study reveals that Phe41 may have evolved to provide additional regulation of histone deposition in plants.

Suggested Citation

  • Li Lu & Xiangsong Chen & Shuiming Qian & Xuehua Zhong, 2018. "The plant-specific histone residue Phe41 is important for genome-wide H3.1 distribution," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-02976-9
    DOI: 10.1038/s41467-018-02976-9
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    Cited by:

    1. Ting Zhao & Jingyun Lu & Huairen Zhang & Mande Xue & Jie Pan & Lijun Ma & Frédéric Berger & Danhua Jiang, 2022. "Histone H3.3 deposition in seed is essential for the post-embryonic developmental competence in Arabidopsis," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Junhui Yuan & Sanjie Jiang & Jianbo Jian & Mingyu Liu & Zhen Yue & Jiabao Xu & Juan Li & Chunyan Xu & Lihong Lin & Yi Jing & Xiaoxiao Zhang & Haixin Chen & Linjuan Zhang & Tao Fu & Shuiyan Yu & Zhangy, 2022. "Genomic basis of the giga-chromosomes and giga-genome of tree peony Paeonia ostii," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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